| Gene Symbol |
NDST1
|
| Entrez Gene |
3340
|
| Alt Symbol |
HSST, MRT46, NST1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
|
| Other Description |
HSNST 1|N-HSST 1|N-heparan sulfate sulfotransferase 1|NDST-1|[Heparan sulfate]-glucosamine N-sulfotransferase 1|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1|glucosaminyl N-deacetylase/N-sulfotransferase 1|heparan sulfate-N-deacetylase/N-sulfotransferase
|
| Swissprots |
Q96E57 P52848
|
| Accessions |
EAW61720 EAW61721 EAW61722 P52848 AB209107 BAD92344 AK292448 BAF85137 AK293746 BAH11586 BC012888 AAH12888 BC015828 ES315645 U17970 AAA67765 U18918 AAA75281 U18932 U36600 AAC27354 XM_005268433 XP_005268490 XM_005268434 XP_005268491 XM_005268435 XP_005268492 XM_005268436 XP_005268493 XM_005268437 XP_005268494 XM_005268438 XP_005268495 XM_005268439 XP_005268496 XM_005268441 XP_005268498 XM_005268442 XP_005268499 XM_006714782 XP_006714845 XM_006714783 XP_006714846 XM_011537638 XP_011535940 XR_245854 NM_001301063 NP_001287992 NM_001543 NP_001534
|
| Function |
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response. {ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:12634318}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000269|PubMed:9230113}; Single-pass type II membrane protein {ECO:0000269|PubMed:9230113}.
|
| Tissue Specificity |
Widely expressed. Expression is most abundant in heart, liver and pancreas.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|