NDST1

Gene Symbol	NDST1
Entrez Gene	3340
Alt Symbol	HSST, MRT46, NST1
Species	Human
Gene Type	protein-coding
Description	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Other Description	HSNST 1|N-HSST 1|N-heparan sulfate sulfotransferase 1|NDST-1|[Heparan sulfate]-glucosamine N-sulfotransferase 1|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1|glucosaminyl N-deacetylase/N-sulfotransferase 1|heparan sulfate-N-deacetylase/N-sulfotransferase
Swissprots	Q96E57 P52848
Accessions	EAW61720 EAW61721 EAW61722 P52848 AB209107 BAD92344 AK292448 BAF85137 AK293746 BAH11586 BC012888 AAH12888 BC015828 ES315645 U17970 AAA67765 U18918 AAA75281 U18932 U36600 AAC27354 XM_005268433 XP_005268490 XM_005268434 XP_005268491 XM_005268435 XP_005268492 XM_005268436 XP_005268493 XM_005268437 XP_005268494 XM_005268438 XP_005268495 XM_005268439 XP_005268496 XM_005268441 XP_005268498 XM_005268442 XP_005268499 XM_006714782 XP_006714845 XM_006714783 XP_006714846 XM_011537638 XP_011535940 XR_245854 NM_001301063 NP_001287992 NM_001543 NP_001534
Function	Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response. {ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:12634318}.
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:9230113}; Single-pass type II membrane protein {ECO:0000269|PubMed:9230113}.
Tissue Specificity	Widely expressed. Expression is most abundant in heart, liver and pancreas.
Top Pathways	Glycosaminoglycan biosynthesis - heparan sulfate / heparin

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NDST1 protein fragment - ab116875 from Abcam Category Protein Source Wheat germ Species Human

NDST1 Antibody Blocking Peptide - LS-E2284 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

N-Deacetylase/N-Sulfotransferase 1/NDST1 Partial Recombinant Protein - H00003340-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human N-Deacetylase/N-Sulfotransferase 1/NDST1 Protein - H00003340-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

NDST1-Antibody-C-term-Blocking-Peptide - BP13224b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human NDST1, CF - 5967-ST-010 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Ser79-Arg882, with a C-terminal 6-His tag

Human NDST1 protein - orb244398 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

NDST1 - H00003340-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

NDST1 - H00003340-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NDST1 - H00003340-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NDST1 fusion protein - ag3057 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NDST1 - NDST1-28794TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase - CSB-YP015614HU CSB-BP015614HU CSB-MP015614HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase - CSB-EP015614HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human NDST1 Protein, CF - 5967-ST from R&D Systems Category Protein Prices $329.00 Sizes 10 µg Source Chinese Hamster Ovary cell line, CHO-derived Ser79-Arg882, with a C-terminal 6-His tag Species Human

NDST1 - TP321638 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

N-Deacetylase/N-Sulfotransferase 1/NDST1 Recombinant Protein Antigen - NBP2-37978PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NDST1 Peptide, Human - M34GP10223H from Creative Peptides Category Peptide Source Synthetic. Species Human

NDST1 Recombinant Protein (OPCA01747) - OPCA01747 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1(NDST1) - RPC20063 from Biomatik Category Protein Prices $106.00, $242.00, $380.00, $594.00, $945.00, $1,424.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Recombinant human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 - AP70578 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, Recombinant Protein - MBS9420487 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

Heparan sulfate N-deacetylase/N-sulfotransferase 1, Recombinant Protein - MBS966196 from MyBioSource Category Protein Prices $180.00, $490.00, $715.00, $950.00, $1,170.00, $1,170.00, $1,170.00, $1,400.00, $1,860.00, $1,860.00, $1,860.00, $2,760.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 1 mg (E-Coli), 50 µg (Mammalian-Cell), 500 µg (Yeast), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Human NDST1 Protein, CF - 5967-ST from Novus Biologicals Category Protein Prices $329.00 Sizes 10 µg Species Human

NDST1 fusion protein - Ag24422 from Proteintech Group Category Protein Source E. coli -derived, PET30a Species Human

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