| Gene Symbol |
FIG4
|
| Entrez Gene |
9896
|
| Alt Symbol |
ALS11, BTOP, CMT4J, KIAA0274, SAC3, YVS, dJ249I4.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FIG4 phosphoinositide 5-phosphatase
|
| Other Description |
FIG4 homolog, SAC domain containing lipid phosphatase|FIG4 homolog, SAC1 domain containing lipid phosphatase|FIG4 homolog, SAC1 lipid phosphatase domain containing|SAC domain-containing protein 3|Sac domain-containing inositol phosphatase 3|phosphatidylinositol 3,5-bisphosphate 5-phosphatase|polyphosphoinositide phosphatase
|
| Swissprots |
Q53H49 Q92562 Q5TCS6
|
| Accessions |
EAW48332 Q92562 AA815086 AA946705 AI476769 AK222732 BAD96452 AK291671 BAF84360 AK293422 BAG56929 BC041338 AAH41338 BM016965 BU683891 D87464 BAA13403 DA811740 XM_011536281 XP_011534583 NM_014845 NP_055660
|
| Function |
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:17556371}.
|
| Subcellular Location |
Endosome membrane {ECO:0000269|PubMed:17556371}. Note=Localization requires VAC14 and PIKFYVE.
|