PIK3R2
| Gene Symbol | PIK3R2 |
|---|---|
| Entrez Gene | 5296 |
| Alt Symbol | MPPH, MPPH1, P85B, p85, p85-BETA |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
| Other Description | PI3-kinase subunit p85-beta|PI3K regulatory subunit beta|phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta|phosphatidylinositol 3-kinase regulatory subunit beta|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)|ptdIns-3-kinase regulatory subunit p85-beta |
| Swissprots | Q5EAT5 O00459 Q9UPH9 |
| Accessions | AAD22671 EAW84659 EAW84660 O00459 BC011917 AAH11917 BC014170 AAH14170 BC032647 AAH32647 BC070082 AAH70082 BC090249 AAH90249 HY043384 X80907 CAA56868 NM_005027 NP_005018 NR_073517 |
| Function | Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). {ECO:0000250|UniProtKB:O08908, ECO:0000269|PubMed:23604317}. |
| Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |
Cow PI 3 Kinase p85 beta full length protein - ab91399 from Abcam
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Human PI 3 Kinase p85 beta full length protein - ab125568 from Abcam
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PIK3R2 / p85 Beta Antibody Blocking Peptide - LS-E9433 from LifeSpan Bioscience
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PIK3R2 / p85 Beta Antibody Blocking Peptide - LS-E9437 from LifeSpan Bioscience
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PIK3R2 / p85 Beta Antibody Blocking Peptide - LS-E9439 from LifeSpan Bioscience
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PIK3R2 / p85 Beta Antibody Blocking Peptide - LS-E9438 from LifeSpan Bioscience
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PI 3-Kinase p85 beta Peptide - P3011 from Novus Biologicals
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PI 3-Kinase p85 beta Peptide - P3010 from Novus Biologicals
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PI 3-Kinase p85 beta Peptide - P3009 from Novus Biologicals
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PI 3-Kinase p85 beta Peptide - P3004 from Novus Biologicals
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PIK3R2-Antibody-Y464-Blocking-Peptide - BP8028d from Abgent, a WuXi AppTec company
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PIK3R2-Antibody-Y467-Blocking-Peptide - BP8028c from Abgent, a WuXi AppTec company
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PIK3R2-Antibody-N-term-Blocking-Peptide - BP8028a from Abgent, a WuXi AppTec company
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PI3KR2-Antibody-C-term-Blocking-Peptide - BP8024b from Abgent, a WuXi AppTec company
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p85 beta protein - orb85156 from Biorbyt
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PIK3R2 peptide - orb217754 from Biorbyt
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PIK3R2 fusion protein - ag14369 from Proteintech Group
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PIK3R2 fusion protein - ag14367 from Proteintech Group
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Recombinant Human Phosphoinositide-3-kinase, Regulatory Subunit 2 (Beta) - PIK3R2-51H from Creative Biomart
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Recombinant Human PIK3R2, His-tagged - PIK3R2-1718H from Creative Biomart
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PI3K (p85 beta) protein-HIS Epitope - 009-001-S95 from Rockland Immunochemicals Inc
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PI3K (p85 beta) protein-HIS Epitope - 009-001-S95S from Rockland Immunochemicals Inc
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PI3K p85 beta Blocking Peptide - CBP1891 from Cohesion Biosciences
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PI3K p85 beta Blocking Peptide - CBP1892 from Cohesion Biosciences
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PI3K p85β (Q496) Peptide - BS2827P from Bioworld Technology
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