PIK3R2

Gene Symbol PIK3R2
Entrez Gene 5296
Alt Symbol MPPH, MPPH1, P85B, p85, p85-BETA
Species Human
Gene Type protein-coding
Description phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Other Description PI3-kinase subunit p85-beta|PI3K regulatory subunit beta|phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta|phosphatidylinositol 3-kinase regulatory subunit beta|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)|ptdIns-3-kinase regulatory subunit p85-beta
Swissprots Q5EAT5 O00459 Q9UPH9
Accessions AAD22671 EAW84659 EAW84660 O00459 BC011917 AAH11917 BC014170 AAH14170 BC032647 AAH32647 BC070082 AAH70082 BC090249 AAH90249 HY043384 X80907 CAA56868 NM_005027 NP_005018 NR_073517
Function Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). {ECO:0000250|UniProtKB:O08908, ECO:0000269|PubMed:23604317}.
Top Pathways Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

PI 3-kinase p85α/β/γ (D-9) - sc-374534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PI 3-kinase p85α/β/γ (D-9): sc-374534. Western blot analysis of PI 3-kinase p85α expression in non-transfected: sc-117752 (A) and mouse PI 3-kinase p85α transfected: sc-122557 (B) 293T whole cell lysates.

PI 3-kinase p85α/β/γ (H-274) - sc-292114 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PI 3-kinase p85α/β/γ (H-274): sc-292114. Western blot analysis of PI 3-kinase p85β expression in non-transfected: sc-117752 (A) and human PI 3-kinase p85β transfected: sc-112567 (B) 293T whole cell lysates.

PI 3-kinase p85β (K-12) - sc-131324 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PI 3-kinase p85β (N-14) - sc-131325 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PI 3-kinase p85β (N-14): sc-131325. Western blot analysis of PI 3-kinase p85β expression in BJAB (A) and K-562 (B) whole cell lysates.

Anti-PI 3 Kinase p85 beta (phospho Y464) antibody - ab138364 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PI 3 Kinase p85 beta (phospho Y464) antibody (ab138364) at 1/500 dilution + Jurkat cell extract at 30 µg

Anti-PI 3 Kinase p85 beta antibody - ab62901 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab62901 stained HepG2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab62901 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PI 3 Kinase p85 beta antibody - ab131067 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human Mammary Cancer Tissue labelled with ab131067 PI 3 Kinase p85 beta antibody at 1 µg/ml.

Anti-PI 3 Kinase p85 beta antibody - ab71052 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PI 3 Kinase p85 beta antibody (ab71052) at 1/50 dilutionLane 1 : 293 cell lysate, non transfected Lane 2 : 293 cell lysate, transiently transfected with the PI 3 Kinase p85 beta gene Lysates/proteins at 2 µg per lane.

Anti-PI 3 Kinase p85 beta antibody - ab93778 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PI 3 Kinase p85 beta antibody (ab93778) at 0.04 µg/mlLane 1 : Hela cell lysate at 50 µgLane 2 : Hela cell lysate at 15 µgLane 3 : HeLa cell lysate at 5 µgdeveloped using the ECL technique

Anti-PI 3 Kinase p85 beta antibody - ab5456 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PI 3 Kinase p85 beta antibody - ab70956 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PI 3 Kinase p85 beta antibody (ab70956) at 1/50 dilutionLane 1 : 293 cell lysates (nontransfected)Lane 2 : 293 cell lysates transiently transfected with the PI 3 Kinase p85 beta geneLysates/proteins at 2 µg per lane.

Anti-PI 3 Kinase p85 beta antibody - ab93642 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab93642, at 1/100 dilution, showing cytoplasmic staining of PI 3 Kinase p85 beta in formalin-fixed, paraffin-embedded Human brain tissue by Immunohistochemistry.

Anti-PI 3 Kinase p85 beta antibody [EPR18416] - ab180967 from Abcam

Prices $99.00, $347.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR18416
All lanes : Anti-PI 3 Kinase p85 beta antibody [EPR18416] (ab180967) at 1/2000 dilutionLane 1 : HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysateLane 2 : Jurkat (Human T cell leukemia cells from peripheral blood) whole cell lysateLane 3 : HEK293 (Human epithelial cells from embryonic kidney) whole cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/1000 dilution

Anti-PI 3 Kinase p85 beta antibody [T15] - ab28356 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone T15

Anti-PI 3 Kinase p85 beta antibody [T15] - ab252 from Abcam

Host Mouse
Clonality Monoclonal
Clone T15

Anti-PIK3R2 / p85 Beta Antibody - LS-C124372 from LifeSpan Bioscience

Prices $485.00
Sizes 2 ml
Host Mouse
Clonality Monoclonal

Anti-PIK3R2 / p85 Beta Antibody - LS-C131399 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PIK3R2 / p85 Beta Antibody (aa516-642, clone 12K162) - LS-C182930 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 12K162

Anti-PIK3R2 / p85 Beta Antibody (aa447-496) - LS-C199968 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PIK3R2 / p85 Beta Antibody (aa276-305, AP) - LS-C239011 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R2 / p85 Beta Antibody (aa276-305, APC) - LS-C239012 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R2 / p85 Beta Antibody (aa276-305, FITC) - LS-C239014 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R2 / p85 Beta Antibody (aa276-305, Biotin) - LS-C239013 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R2 / p85 Beta Antibody (aa276-305, PE) - LS-C239018 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R2 / p85 Beta Antibody (Tyr464, AP) - LS-C239056 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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