| Gene Symbol | PIK3R2 |
|---|---|
| Entrez Gene | 5296 |
| Alt Symbol | MPPH, MPPH1, P85B, p85, p85-BETA |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
| Other Description | PI3-kinase subunit p85-beta|PI3K regulatory subunit beta|phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta|phosphatidylinositol 3-kinase regulatory subunit beta|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)|ptdIns-3-kinase regulatory subunit p85-beta |
| Swissprots | Q5EAT5 O00459 Q9UPH9 |
| Accessions | AAD22671 EAW84659 EAW84660 O00459 BC011917 AAH11917 BC014170 AAH14170 BC032647 AAH32647 BC070082 AAH70082 BC090249 AAH90249 HY043384 X80907 CAA56868 NM_005027 NP_005018 NR_073517 |
| Function | Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). {ECO:0000250|UniProtKB:O08908, ECO:0000269|PubMed:23604317}. |
| Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |
PI 3-kinase p85β CRISPR/Cas9 KO Plasmid (h) - sc-401991 from Santa Cruz Biotechnology
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PI 3-kinase p85β HDR Plasmid (h) - sc-401991-HDR from Santa Cruz Biotechnology
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PI 3-kinase p85β Double Nickase Plasmid (h) - sc-401991-NIC from Santa Cruz Biotechnology
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PI 3-kinase p85β Double Nickase Plasmid (h2) - sc-401991-NIC-2 from Santa Cruz Biotechnology
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PI 3-kinase p85β CRISPR Activation Plasmid (h) - sc-401991-ACT from Santa Cruz Biotechnology
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PI 3-kinase p85β CRISPR Activation Plasmid (h2) - sc-401991-ACT-2 from Santa Cruz Biotechnology
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PI 3-kinase p85β Lentiviral Activation Particles (h) - sc-401991-LAC from Santa Cruz Biotechnology
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PI 3-kinase p85β Lentiviral Activation Particles (h2) - sc-401991-LAC-2 from Santa Cruz Biotechnology
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PI 3-kinase p85β siRNA (h) - sc-39125 from Santa Cruz Biotechnology
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PI 3-kinase p85β shRNA Plasmid (h) - sc-39125-SH from Santa Cruz Biotechnology
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PI 3-kinase p85β shRNA (h) Lentiviral Particles - sc-39125-V from Santa Cruz Biotechnology
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PI 3-Kinase p85 beta RNAi - H00005296-R02 from Novus Biologicals
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MISSION® siRNA - SIHK1664 from Sigma-Aldrich
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MISSION® siRNA - SIHK1665 from Sigma-Aldrich
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MISSION® siRNA - SIHK1666 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16811 from Sigma-Aldrich
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PIK3R2 siRNA (Human) - CRH3541 from Cohesion Biosciences
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PI 3-kinase p85β CRISPR/Cas9 KO Plasmid (h2) - sc-401991-KO-2 from Santa Cruz Biotechnology
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PI 3-kinase p85β HDR Plasmid (h2) - sc-401991-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PIK3R2 (NM_005027.2) - SHH375784 from Creative biogene
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shRNA set against Human PIK3R2(NM_005027.2) - SHR114810 from Creative biogene
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Human PIK3R2 siRNA - orb264043 from Biorbyt
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PIK3R2 shRNA Plasmid (Human) - CHH3541 from Cohesion Biosciences
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PIK3R2 miRNA 3'UTR clone - MiUTR1H-07911 from Creative biogene
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