| Gene Symbol |
GOLM1
|
| Entrez Gene |
51280
|
| Alt Symbol |
C9orf155, GOLPH2, GP73, HEL46, PSEC0257, bA379P1.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
golgi membrane protein 1
|
| Other Description |
Golgi membrane protein 1|epididymis luminal protein 46|golgi membrane protein GP73|golgi phosphoprotein 2|golgi protein, 73-kD
|
| Swissprots |
Q8NBJ4 Q9NRB9 Q6IAF4
|
| Accessions |
AAM87790 AAM87857 CAD32484 CAI72214 CAK32495 EAW62705 EAW62706 Q8NBJ4 AF236056 AAF44663 AI929234 AJ420432 AK027717 BAG51371 AK074188 BAB85012 AK075542 BAC11685 AK075557 BAG52167 AK092943 AL533767 AY358593 AAQ88956 BC001740 AAH01740 BQ216766 CA446701 CR457201 CAG33482 DA116177 EU794616 ACJ13670 HQ447901 ADQ32385 NM_016548 NP_057632 NM_177937 NP_808800 NM_001099268
|
| Function |
Unknown. Cellular response protein to viral infection.
|
| Subcellular Location |
Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}; Single-pass type II membrane protein {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
|
| Tissue Specificity |
Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes. {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12029628}.
|
![Western Blot: GOLM1 Overexpression Lysate (Adult Normal) [NBL1-11198] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GOLM1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3696_GOLM1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11198-img0002.jpg)