Gene Symbol | GOLM1 |
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Entrez Gene | 51280 |
Alt Symbol | C9orf155, GOLPH2, GP73, HEL46, PSEC0257, bA379P1.3 |
Species | Human |
Gene Type | protein-coding |
Description | golgi membrane protein 1 |
Other Description | Golgi membrane protein 1|epididymis luminal protein 46|golgi membrane protein GP73|golgi phosphoprotein 2|golgi protein, 73-kD |
Swissprots | Q8NBJ4 Q9NRB9 Q6IAF4 |
Accessions | AAM87790 AAM87857 CAD32484 CAI72214 CAK32495 EAW62705 EAW62706 Q8NBJ4 AF236056 AAF44663 AI929234 AJ420432 AK027717 BAG51371 AK074188 BAB85012 AK075542 BAC11685 AK075557 BAG52167 AK092943 AL533767 AY358593 AAQ88956 BC001740 AAH01740 BQ216766 CA446701 CR457201 CAG33482 DA116177 EU794616 ACJ13670 HQ447901 ADQ32385 NM_016548 NP_057632 NM_177937 NP_808800 NM_001099268 |
Function | Unknown. Cellular response protein to viral infection. |
Subcellular Location | Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}; Single-pass type II membrane protein {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption. |
Tissue Specificity | Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes. {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12029628}. |
GP73 CRISPR/Cas9 KO Plasmid (h) - sc-401581 from Santa Cruz Biotechnology
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GP73 HDR Plasmid (h) - sc-401581-HDR from Santa Cruz Biotechnology
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GP73 Double Nickase Plasmid (h) - sc-401581-NIC from Santa Cruz Biotechnology
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GP73 Double Nickase Plasmid (h2) - sc-401581-NIC-2 from Santa Cruz Biotechnology
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GP73 CRISPR Activation Plasmid (h) - sc-401581-ACT from Santa Cruz Biotechnology
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GP73 CRISPR Activation Plasmid (h2) - sc-401581-ACT-2 from Santa Cruz Biotechnology
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GP73 Lentiviral Activation Particles (h) - sc-401581-LAC from Santa Cruz Biotechnology
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GP73 Lentiviral Activation Particles (h2) - sc-401581-LAC-2 from Santa Cruz Biotechnology
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GP73 siRNA (h) - sc-60711 from Santa Cruz Biotechnology
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GP73 shRNA Plasmid (h) - sc-60711-SH from Santa Cruz Biotechnology
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GP73 shRNA (h) Lentiviral Particles - sc-60711-V from Santa Cruz Biotechnology
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GOLM1 RNAi - H00051280-R02 from Novus Biologicals
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MISSION® esiRNA - EHU046671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9479 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9479 from Sigma-Aldrich
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GOLM1 siRNA (Human) - CRH9658 from Cohesion Biosciences
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GOLM1 RNAi - H00051280-R01 from Novus Biologicals
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GOLM1 - MBS8208492 from MyBioSource
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shRNA set against Human GOLM1 (NM_177937.2) - SHH305342 from Creative biogene
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Human GOLM1 siRNA - orb270160 from Biorbyt
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GOLM1 shRNA Plasmid (Human) - CHH9658 from Cohesion Biosciences
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GOLM1 miRNA 3'UTR clone - MiUTR3H-08726 from Creative biogene
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GOLM1 miRNA 3'UTR clone - MiUTR3H-08727 from Creative biogene
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