Gene Symbol | MVB12A |
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Entrez Gene | 93343 |
Alt Symbol | CFBP, FAM125A |
Species | Human |
Gene Type | protein-coding |
Description | multivesicular body subunit 12A |
Other Description | CIN85/CD2AP family binding protein|ESCRT-I complex subunit MVB12A|family with sequence similarity 125, member A |
Swissprots | Q96I18 Q96EY5 |
Accessions | CAC38635 EAW84604 EAW84605 Q96EY5 AK057057 AK289487 BAF82176 BC007883 AAH07883 BC011840 AAH11840 BG684013 BP394542 BY996463 CD672349 DR006745 HG510441 HG510444 NM_001304547 NP_001291476 NM_138401 NP_612410 |
Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor. {ECO:0000269|PubMed:16895919}. |
Subcellular Location | Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Colocalizes with F-actin. Some fraction may be nuclear. |
Tissue Specificity | Ubiquitously expressed except in skeletal muscle. {ECO:0000269|PubMed:16895919}. |
Top Pathways | Endocytosis |
CFBP CRISPR/Cas9 KO Plasmid (h) - sc-409502 from Santa Cruz Biotechnology
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CFBP HDR Plasmid (h) - sc-409502-HDR from Santa Cruz Biotechnology
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CFBP Double Nickase Plasmid (h) - sc-409502-NIC from Santa Cruz Biotechnology
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CFBP Double Nickase Plasmid (h2) - sc-409502-NIC-2 from Santa Cruz Biotechnology
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CFBP CRISPR Activation Plasmid (h) - sc-409502-ACT from Santa Cruz Biotechnology
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CFBP CRISPR Activation Plasmid (h2) - sc-409502-ACT-2 from Santa Cruz Biotechnology
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CFBP Lentiviral Activation Particles (h) - sc-409502-LAC from Santa Cruz Biotechnology
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CFBP Lentiviral Activation Particles (h2) - sc-409502-LAC-2 from Santa Cruz Biotechnology
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MVB12A siRNA (h) - sc-97374 from Santa Cruz Biotechnology
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MVB12A shRNA Plasmid (h) - sc-97374-SH from Santa Cruz Biotechnology
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MVB12A shRNA (h) Lentiviral Particles - sc-97374-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU018641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8154 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8154 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03152 from Sigma-Aldrich
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MVB12A siRNA (Human) - CRJ4202 from Cohesion Biosciences
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shRNA set against Human FAM125A (NM_138401.2) - SHH289421 from Creative biogene
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Human MVB12A siRNA - orb274703 from Biorbyt
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MVB12A shRNA Plasmid (Human) - CHJ4202 from Cohesion Biosciences
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FAM125A miRNA 3'UTR clone - MiUTR1H-03412 from Creative biogene
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