Gene Symbol | RIC8B |
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Entrez Gene | 55188 |
Alt Symbol | RIC8, hSyn |
Species | Human |
Gene Type | protein-coding |
Description | RIC8 guanine nucleotide exchange factor B |
Other Description | brain synembrin|brain synembryn|resistance to inhibitors of cholinesterase 8 homolog B|synembryn-B |
Swissprots | Q4G103 A2RTZ0 Q86WD3 Q6ZRN4 Q9NVN3 |
Accessions | CAE89453 EAW97785 EAW97786 EAW97787 Q9NVN3 AK001482 BAA91717 AK128102 AY221116 AAO65923 BC034220 AAH34220 BC132689 AAI32690 BC144056 AAI44057 CB215722 DA118965 DA325821 DA534432 XM_005268998 XP_005269055 XM_011538526 XP_011536828 XM_011538527 XP_011536829 XM_011538528 XP_011536830 XM_011538529 XP_011536831 XR_245940 XR_944604 XR_944605 XR_944606 XR_944607 XR_944608 NM_018157 NP_060627 |
Function | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. {ECO:0000250}. |
Subcellular Location | Cytoplasm, cell cortex {ECO:0000269|PubMed:12652642}. Note=Localizes to the cell cortex. |
RIC-8B CRISPR/Cas9 KO Plasmid (h) - sc-409133 from Santa Cruz Biotechnology
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RIC-8B HDR Plasmid (h) - sc-409133-HDR from Santa Cruz Biotechnology
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RIC-8B Double Nickase Plasmid (h) - sc-409133-NIC from Santa Cruz Biotechnology
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RIC-8B Double Nickase Plasmid (h2) - sc-409133-NIC-2 from Santa Cruz Biotechnology
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RIC-8B CRISPR Activation Plasmid (h) - sc-409133-ACT from Santa Cruz Biotechnology
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RIC-8B CRISPR Activation Plasmid (h2) - sc-409133-ACT-2 from Santa Cruz Biotechnology
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RIC-8B Lentiviral Activation Particles (h) - sc-409133-LAC from Santa Cruz Biotechnology
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RIC-8B Lentiviral Activation Particles (h2) - sc-409133-LAC-2 from Santa Cruz Biotechnology
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RIC-8B siRNA (h) - sc-95876 from Santa Cruz Biotechnology
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RIC-8B shRNA Plasmid (h) - sc-95876-SH from Santa Cruz Biotechnology
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RIC-8B shRNA (h) Lentiviral Particles - sc-95876-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU059091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18274 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18274 from Sigma-Aldrich
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RIC8B siRNA (Human) - CRJ0540 from Cohesion Biosciences
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RIC8B - MBS827779 from MyBioSource
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shRNA set against Human Ric8 (NM_018157.2) - SHH395672 from Creative biogene
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shRNA set against Human RIC8B(NM_018157.2) - SHR182002 from Creative biogene
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RIC8B shRNA Plasmid (Human) - CHJ0540 from Cohesion Biosciences
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RIC8B miRNA 3'UTR clone - MiUTR1H-08821 from Creative biogene
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