| Gene Symbol |
CABIN1
|
| Entrez Gene |
23523
|
| Alt Symbol |
CAIN, PPP3IN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcineurin binding protein 1
|
| Other Description |
calcineurin binding protein cabin 1|calcineurin inhibitor|calcineurin-binding protein cabin-1
|
| Swissprots |
Q9Y6J0 Q6PHY0 G5E9F3 Q9Y460
|
| Accessions |
CAB62954 EAW59637 EAW59638 EAW59639 EAW59640 Q9Y6J0 AB002328 BAA20788 AF072441 AAD40846 AK127950 AK307522 AL390166 CAB99097 AL703593 BC013099 BC021929 AAH21929 BC028969 AAH28969 BC041659 AAH41659 BC054497 AAH54497 HG512085 XM_005261415 XP_005261472 XM_005261416 XP_005261473 XM_005261417 XP_005261474 XM_005261419 XP_005261476 XM_005261420 XP_005261477 XM_006724179 XP_006724242 XM_006724180 XP_006724243 XM_006724181 XP_006724244 XM_006724182 XP_006724245 XM_006724184 XP_006724247 XM_011530026 XP_011528328 XM_011530027 XP_011528329 XM_011530028 XP_011528330 XM_011530029 XP_011528331 XM_011530030 XP_011528332 XM_011530031 XP_011528333 XM_011530032 XP_011528334 XM_011530033 XP_011528335 NM_001199281 NP_001186210 NM_001201429 NP_001188358 NM_012295 NP_036427
|
| Function |
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9655484}.
|
| Tissue Specificity |
Widely expressed in different tissues. {ECO:0000269|PubMed:9655484}.
|