Gene Symbol | CABIN1 |
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Entrez Gene | 23523 |
Alt Symbol | CAIN, PPP3IN |
Species | Human |
Gene Type | protein-coding |
Description | calcineurin binding protein 1 |
Other Description | calcineurin binding protein cabin 1|calcineurin inhibitor|calcineurin-binding protein cabin-1 |
Swissprots | Q9Y6J0 Q6PHY0 G5E9F3 Q9Y460 |
Accessions | CAB62954 EAW59637 EAW59638 EAW59639 EAW59640 Q9Y6J0 AB002328 BAA20788 AF072441 AAD40846 AK127950 AK307522 AL390166 CAB99097 AL703593 BC013099 BC021929 AAH21929 BC028969 AAH28969 BC041659 AAH41659 BC054497 AAH54497 HG512085 XM_005261415 XP_005261472 XM_005261416 XP_005261473 XM_005261417 XP_005261474 XM_005261419 XP_005261476 XM_005261420 XP_005261477 XM_006724179 XP_006724242 XM_006724180 XP_006724243 XM_006724181 XP_006724244 XM_006724182 XP_006724245 XM_006724184 XP_006724247 XM_011530026 XP_011528328 XM_011530027 XP_011528329 XM_011530028 XP_011528330 XM_011530029 XP_011528331 XM_011530030 XP_011528332 XM_011530031 XP_011528333 XM_011530032 XP_011528334 XM_011530033 XP_011528335 NM_001199281 NP_001186210 NM_001201429 NP_001188358 NM_012295 NP_036427 |
Function | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9655484}. |
Tissue Specificity | Widely expressed in different tissues. {ECO:0000269|PubMed:9655484}. |
Cabin-1 CRISPR/Cas9 KO Plasmid (h) - sc-417118 from Santa Cruz Biotechnology
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Cabin-1 HDR Plasmid (h) - sc-417118-HDR from Santa Cruz Biotechnology
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Cabin-1 Double Nickase Plasmid (h) - sc-417118-NIC from Santa Cruz Biotechnology
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Cabin-1 Double Nickase Plasmid (h2) - sc-417118-NIC-2 from Santa Cruz Biotechnology
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Cabin-1 CRISPR Activation Plasmid (h) - sc-417118-ACT from Santa Cruz Biotechnology
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Cabin-1 CRISPR Activation Plasmid (h2) - sc-417118-ACT-2 from Santa Cruz Biotechnology
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Cabin-1 Lentiviral Activation Particles (h) - sc-417118-LAC from Santa Cruz Biotechnology
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Cabin-1 Lentiviral Activation Particles (h2) - sc-417118-LAC-2 from Santa Cruz Biotechnology
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Cabin-1 siRNA (h) - sc-43652 from Santa Cruz Biotechnology
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Cabin-1 shRNA Plasmid (h) - sc-43652-SH from Santa Cruz Biotechnology
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Cabin-1 shRNA (h) Lentiviral Particles - sc-43652-V from Santa Cruz Biotechnology
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CAIN RNAi - H00023523-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN5252 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5252 from Sigma-Aldrich
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CABIN1 siRNA (Human) - CRH8329 from Cohesion Biosciences
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CABIN1 - MBS8219887 from MyBioSource
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shRNA set against Human Cabin1 (NM_012295.3) - SHH253125 from Creative biogene
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Human CABIN1 siRNA - orb268831 from Biorbyt
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CABIN1 shRNA Plasmid (Human) - CHH8329 from Cohesion Biosciences
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CABIN1 miRNA 3'UTR clone - MiUTR3H-06676 from Creative biogene
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