ATP5J
| Gene Symbol | ATP5J |
|---|---|
| Entrez Gene | 522 |
| Alt Symbol | ATP5, ATP5A, ATPM, CF6, F6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 |
| Other Description | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6|ATP synthase-coupling factor 6, mitochondrial|ATPase subunit F6|coupling factor 6|mitochondrial ATP synthase, coupling factor 6|mitochondrial ATP synthase, subunit F6|mitochondrial ATPase coupling factor 6|proliferation-inducing protein 36 |
| Swissprots | J3KQ83 P18859 |
| Accessions | CAE94071 EAX09970 EAX09971 EAX09972 EAX09973 EAX09974 EAX09975 P18859 AI085837 AK311899 BAG34840 AL110183 CAB53667 AY544129 AAT11160 BC001178 AAH01178 BC066310 AAH66310 BG938438 BI093033 BQ268216 BT007244 AAP35908 BU174560 CR456950 CAG33231 M37104 AAA51807 M73031 AAA58630 XM_005260992 XP_005261049 NM_001003696 NP_001003696 NM_001003697 NP_001003697 NM_001003701 NP_001003701 NM_001003703 NP_001003703 NM_001685 NP_001676 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes. |
| Subcellular Location | Mitochondrion. Mitochondrion inner membrane. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |
ATP5J CRISPR/Cas9 KO Plasmid (h) - sc-410697 from Santa Cruz Biotechnology
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ATP5J HDR Plasmid (h) - sc-410697-HDR from Santa Cruz Biotechnology
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ATP5J Double Nickase Plasmid (h) - sc-410697-NIC from Santa Cruz Biotechnology
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ATP5J Double Nickase Plasmid (h2) - sc-410697-NIC-2 from Santa Cruz Biotechnology
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ATP5J CRISPR Activation Plasmid (h) - sc-410697-ACT from Santa Cruz Biotechnology
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ATP5J CRISPR Activation Plasmid (h2) - sc-410697-ACT-2 from Santa Cruz Biotechnology
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ATP5J Lentiviral Activation Particles (h) - sc-410697-LAC from Santa Cruz Biotechnology
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ATP5J Lentiviral Activation Particles (h2) - sc-410697-LAC-2 from Santa Cruz Biotechnology
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ATP5J siRNA (h) - sc-91439 from Santa Cruz Biotechnology
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ATP5J shRNA Plasmid (h) - sc-91439-SH from Santa Cruz Biotechnology
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ATP5J shRNA (h) Lentiviral Particles - sc-91439-V from Santa Cruz Biotechnology
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ATP5J RNAi - H00000522-R05 from Novus Biologicals
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ATP5J RNAi - H00000522-R04 from Novus Biologicals
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ATP5J RNAi - H00000522-R02 from Novus Biologicals
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MISSION® esiRNA - EHU044471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3706 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3706 from Sigma-Aldrich
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ATP5J siRNA (Human) - CRH0361 from Cohesion Biosciences
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ATP5J RNAi - H00000522-R01 from Novus Biologicals
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ATP5J RNAi - H00000522-R03 from Novus Biologicals
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ATP5J - MBS8203824 from MyBioSource
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shRNA set against Human ATP5J (NM_001685.4) - SHH242862 from Creative biogene
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shRNA set against Human ATP5J(NM_001003696.1) - SHG082661 from Creative biogene
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shRNA set against Human ATP5J(NM_001003701.1) - SHG082707 from Creative biogene
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Human ATP5J siRNA - orb260863 from Biorbyt
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