Gene Symbol | CYP11B2 |
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Entrez Gene | 1585 |
Alt Symbol | ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 11, subfamily B, polypeptide 2 |
Other Description | aldosterone synthase|aldosterone-synthesizing enzyme|cytochrome P-450Aldo|cytochrome P-450C18|cytochrome P450 11B2, mitochondrial|cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2|mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2|steroid 11-beta-monooxygenase|steroid 11-beta/18-hydroxylase|steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo |
Swissprots | Q16726 P19099 B0ZBE4 |
Accessions | AAA35741 AAB34642 AAB34643 ACA05912 BAA01040 BAA02899 EAW82292 P19099 BC111458 AAI11459 X54741 CAA38539 XM_011516877 XP_011515179 XM_011516878 XP_011515180 XM_011516879 XP_011515181 NM_000498 NP_000489 |
Function | Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone. {ECO:0000269|PubMed:23322723}. |
Subcellular Location | Mitochondrion membrane. |
Top Pathways | Steroid hormone biosynthesis |
CYP11B2 CRISPR/Cas9 KO Plasmid (h) - sc-405281 from Santa Cruz Biotechnology
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CYP11B2 HDR Plasmid (h) - sc-405281-HDR from Santa Cruz Biotechnology
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CYP11B2 Double Nickase Plasmid (h) - sc-405281-NIC from Santa Cruz Biotechnology
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CYP11B2 Double Nickase Plasmid (h2) - sc-405281-NIC-2 from Santa Cruz Biotechnology
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CYP11B2 CRISPR Activation Plasmid (h) - sc-405281-ACT from Santa Cruz Biotechnology
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CYP11B2 CRISPR Activation Plasmid (h2) - sc-405281-ACT-2 from Santa Cruz Biotechnology
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CYP11B2 Lentiviral Activation Particles (h) - sc-405281-LAC from Santa Cruz Biotechnology
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CYP11B2 Lentiviral Activation Particles (h2) - sc-405281-LAC-2 from Santa Cruz Biotechnology
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CYP11B2 siRNA (h) - sc-44861 from Santa Cruz Biotechnology
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CYP11B2 shRNA Plasmid (h) - sc-44861-SH from Santa Cruz Biotechnology
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CYP11B2 shRNA (h) Lentiviral Particles - sc-44861-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU152861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1724 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1724 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12645 from Sigma-Aldrich
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CYP11B2 siRNA (Human) - CRH1114 from Cohesion Biosciences
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CYP11B2 RNAi - H00001585-R01 from Novus Biologicals
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CYP11B2 - MBS8200051 from MyBioSource
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shRNA set against Human Cyp11b2 (NM_000498.3) - SHH272825 from Creative biogene
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shRNA set against Human CYP11B2(NM_000498.3) - SHG196489 from Creative biogene
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Human CYP11B2 siRNA - orb261616 from Biorbyt
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CYP11B2 shRNA Plasmid (Human) - CHH1114 from Cohesion Biosciences
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CYP11B2 miRNA 3'UTR clone - MiUTR1H-02608 from Creative biogene
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