CYP11B2

Gene Symbol CYP11B2
Entrez Gene 1585
Alt Symbol ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo
Species Human
Gene Type protein-coding
Description cytochrome P450, family 11, subfamily B, polypeptide 2
Other Description aldosterone synthase|aldosterone-synthesizing enzyme|cytochrome P-450Aldo|cytochrome P-450C18|cytochrome P450 11B2, mitochondrial|cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2|mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2|steroid 11-beta-monooxygenase|steroid 11-beta/18-hydroxylase|steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
Swissprots Q16726 P19099 B0ZBE4
Accessions AAA35741 AAB34642 AAB34643 ACA05912 BAA01040 BAA02899 EAW82292 P19099 BC111458 AAI11459 X54741 CAA38539 XM_011516877 XP_011515179 XM_011516878 XP_011515180 XM_011516879 XP_011515181 NM_000498 NP_000489
Function Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone. {ECO:0000269|PubMed:23322723}.
Subcellular Location Mitochondrion membrane.
Top Pathways Steroid hormone biosynthesis

CYP11B2 (K-16) - sc-47655 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CYP11B2 (K-16): sc-47655. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

Anti-C11B2 antibody - ab170208 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of CEM cells using ab170208 at a 1/10 dilution (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used.

Anti-C11B2 antibody - ab203069 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed and paraffin embedded mouse embryo tissue labeling C11B2 using ab203069 at 1/200 dilution. DAB staining.

Anti-C11B2 antibody - ab151052 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human adrenal gland tissue labelling C11B2 with ab151052. Staining shows strong cytoplasmic positivity in glandular cells.

Anti-C11B2 antibody [EPR10494] - ab168388 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10494
ab168388 showing +ve staining in Human heart muscle tissue.

Anti-C11B2 antibody [EPR10495] - ab167413 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10495
Overlay histogram showing MCF7 cells stained with ab167413 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab167413, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in MCF7 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Aldosterone Synthase / CYP11B2 Antibody (aa175-192) - LS-C6353 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-Aldosterone Synthase / CYP11B2 Antibody (aa127-155, AP) - LS-C208747 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Aldosterone Synthase / CYP11B2 Antibody (aa127-155, APC) - LS-C208748 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Aldosterone Synthase / CYP11B2 Antibody (aa127-155, Biotin) - LS-C208749 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Aldosterone Synthase / CYP11B2 Antibody (aa127-155, FITC) - LS-C208750 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Aldosterone Synthase / CYP11B2 Antibody (C-Terminus) - LS-C107630 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYP11B2 antibody LS-C107630 Western blot of OVCAR-3 cell lysate.

Anti-Aldosterone Synthase / CYP11B2 Antibody (aa127-155, Azide-free, HRP) - LS-C208751 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Aldosterone Synthase / CYP11B2 Antibody (aa127-155, PE) - LS-C208752 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Aldosterone Synthase / CYP11B2 Antibody (aa127-155) - LS-C320713 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Aldosterone Synthase / CYP11B2 Antibody (aa127-155) - LS-C167207 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYP11B2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

CYP11B2 Antibody - NBP1-56518 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CYP11B2 Antibody [NBP1-56518] - Transfected HEK293-CYP11B2, Antibody Titration: 0.2-1 ug/ml

CYP11B2 Antibody - NBP2-13891 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CYP11B2 Antibody [NBP2-13891] - Staining of adrenal gland shows strong cytoplasmic positivity in cortical cells.

CYP11B2 Polyclonal Antibody - bs-10161R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FOXD3 Polyclonal Antibody - bs-11518R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti FOXD3 Polyclonal Antibody, Unconjugated (bs-11518R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

CYP11B2 Polyclonal Antibody - bs-6436R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat liver tissue labeled with CYP11B2 Polyclonal Antibody, Unconjugated (bs-6436R) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, PE conjugated(bs-0295G-PE) used at 1:200 dilution for 40 minutes at 37°C

CYP11B2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-10161R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CYP11B2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-10161R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CYP11B2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-10161R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CYP11B2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-10161R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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