| Gene Symbol |
FCN3
|
| Entrez Gene |
8547
|
| Alt Symbol |
FCNH, HAKA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ficolin (collagen/fibrinogen domain containing) 3
|
| Other Description |
H-ficolin|collagen/fibrinogen domain-containing lectin 3 p35|collagen/fibrinogen domain-containing protein 3|ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)|ficolin 3|ficolin-3
|
| Swissprots |
O75636 Q8WW86 Q6IBJ5
|
| Accessions |
AAU85296 CAF86408 EAX07756 EAX07757 O75636 AK075140 BAC11429 AK309540 AK309576 AY358081 AAQ88448 AY358283 AAQ88650 BC020731 AAH20731 CR456808 CAG33089 DQ892028 ABM82954 DQ895220 ABM86146 XM_011542339 XP_011540641 NM_003665 NP_003656 NM_173452 NP_775628
|
| Function |
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. {ECO:0000269|PubMed:11907111}.
|
| Subcellular Location |
Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct.
|
| Tissue Specificity |
Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells. {ECO:0000269|PubMed:10330454}.
|
![Western Blot: FCN3 Overexpression Lysate (Adult Normal) [NBP2-04434] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FCN3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3971_FCN3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04434-img0001.jpg)