Gene Symbol | FCN3 |
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Entrez Gene | 8547 |
Alt Symbol | FCNH, HAKA1 |
Species | Human |
Gene Type | protein-coding |
Description | ficolin (collagen/fibrinogen domain containing) 3 |
Other Description | H-ficolin|collagen/fibrinogen domain-containing lectin 3 p35|collagen/fibrinogen domain-containing protein 3|ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)|ficolin 3|ficolin-3 |
Swissprots | O75636 Q8WW86 Q6IBJ5 |
Accessions | AAU85296 CAF86408 EAX07756 EAX07757 O75636 AK075140 BAC11429 AK309540 AK309576 AY358081 AAQ88448 AY358283 AAQ88650 BC020731 AAH20731 CR456808 CAG33089 DQ892028 ABM82954 DQ895220 ABM86146 XM_011542339 XP_011540641 NM_003665 NP_003656 NM_173452 NP_775628 |
Function | May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. {ECO:0000269|PubMed:11907111}. |
Subcellular Location | Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct. |
Tissue Specificity | Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells. {ECO:0000269|PubMed:10330454}. |
H-ficolin CRISPR/Cas9 KO Plasmid (h) - sc-409720 from Santa Cruz Biotechnology
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H-ficolin HDR Plasmid (h) - sc-409720-HDR from Santa Cruz Biotechnology
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H-ficolin Double Nickase Plasmid (h) - sc-409720-NIC from Santa Cruz Biotechnology
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H-ficolin Double Nickase Plasmid (h2) - sc-409720-NIC-2 from Santa Cruz Biotechnology
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H-ficolin CRISPR Activation Plasmid (h) - sc-409720-ACT from Santa Cruz Biotechnology
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H-ficolin CRISPR Activation Plasmid (h2) - sc-409720-ACT-2 from Santa Cruz Biotechnology
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H-ficolin Lentiviral Activation Particles (h) - sc-409720-LAC from Santa Cruz Biotechnology
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H-ficolin Lentiviral Activation Particles (h2) - sc-409720-LAC-2 from Santa Cruz Biotechnology
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H-ficolin siRNA (h) - sc-105432 from Santa Cruz Biotechnology
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H-ficolin shRNA Plasmid (h) - sc-105432-SH from Santa Cruz Biotechnology
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H-ficolin shRNA (h) Lentiviral Particles - sc-105432-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU067931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2167 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2167 from Sigma-Aldrich
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FCN3 siRNA (Human) - CRH5618 from Cohesion Biosciences
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FCN3 - MBS8219805 from MyBioSource
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shRNA set against Human FCN3 (NM_173452.1) - SHH293833 from Creative biogene
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shRNA set against Human FCN3(NM_003665.2) - SHH054875 from Creative biogene
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shRNA set against Human FCN3(NM_173452.1) - SHH054893 from Creative biogene
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FCN3 shRNA Plasmid (Human) - CHH5618 from Cohesion Biosciences
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FCN3 miRNA 3'UTR clone - MiUTR1H-03599 from Creative biogene
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FCN3 miRNA 3'UTR clone - MiUTR1H-03600 from Creative biogene
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