| Gene Symbol | Tfec |
|---|---|
| Entrez Gene | 21426 |
| Alt Symbol | BB107417, Tcfec, bHLHe34 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | transcription factor EC |
| Other Description | TFE-C|mTFEC |
| Swissprots | Q3TWR7 Q9WTW4 |
| Accessions | EDL13894 EDL13895 Q9WTW4 AF077742 AAD24426 AK137141 BAE23248 AK156327 BAE33676 AK157426 BAE34087 AK159579 BAE35199 BC052832 BC064770 BC098494 AAH98494 XM_006505035 XP_006505098 XM_006505036 XP_006505099 XM_006505037 XP_006505100 XM_011241053 XP_011239355 NM_031198 NP_112475 |
| Function | Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) (By similarity). Binds to element F in an E-box sequence-specific manner (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269|PubMed:11818452}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. |
| Tissue Specificity | Expressed in osteoclast-like cells (at protein level). Expressed in cells of the mononuclear phagocyte lineage. Expressed in macrophages and in osteoclast-like cells. {ECO:0000269|PubMed:9973413}. |