| Gene Symbol |
Tfec
|
| Entrez Gene |
21426
|
| Alt Symbol |
BB107417, Tcfec, bHLHe34
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transcription factor EC
|
| Other Description |
TFE-C|mTFEC
|
| Swissprots |
Q3TWR7 Q9WTW4
|
| Accessions |
EDL13894 EDL13895 Q9WTW4 AF077742 AAD24426 AK137141 BAE23248 AK156327 BAE33676 AK157426 BAE34087 AK159579 BAE35199 BC052832 BC064770 BC098494 AAH98494 XM_006505035 XP_006505098 XM_006505036 XP_006505099 XM_006505037 XP_006505100 XM_011241053 XP_011239355 NM_031198 NP_112475
|
| Function |
Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) (By similarity). Binds to element F in an E-box sequence-specific manner (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269|PubMed:11818452}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}.
|
| Tissue Specificity |
Expressed in osteoclast-like cells (at protein level). Expressed in cells of the mononuclear phagocyte lineage. Expressed in macrophages and in osteoclast-like cells. {ECO:0000269|PubMed:9973413}.
|