RAD17

Gene Symbol	RAD17
Entrez Gene	5884
Alt Symbol	CCYC, HRAD17, R24L, RAD17SP, RAD24
Species	Human
Gene Type	protein-coding
Description	RAD17 homolog (S. pombe)
Other Description	RAD1 homolog|RF-C activator 1 homolog|RF-C/activator 1 homolog|Rad17-like protein|cell cycle checkpoint protein (RAD17)|cell cycle checkpoint protein RAD17
Swissprots	Q7Z3S4 Q9UNR7 O75714 Q9UPF5 O75943 D3DWA5 A8K8X2 Q9UNK7 Q9UNR8
Accessions	AAD42176 AAT09763 CAB46364 EAW51279 EAW51280 EAW51281 EAW51282 EAW51283 EAW51284 EAW51285 EAW51286 EAW51287 EAW51288 EAW51289 O75943 AF017748 AAD01620 AF076838 AAC95520 AF085736 AAC36334 AF098533 AAC97950 AF098534 AAC97951 AF112263 AAD38878 AF126424 AAD17334 AJ001642 CAA04894 AJ004977 CAA06251 AK292487 BAF85176 AL122068 CAB59244 AM393045 CAL37923 BC018110 BC032304 AAH32304 BX537441 CAD97683 DQ891608 ABM82534 DQ894801 ABM85727 XM_005276774 XP_005276831 XM_011546954 XP_011545256 XM_011546955 XP_011545257 NM_001278622 NP_001265551 NM_002873 NP_002864 NM_133338 NP_579916 NM_133339 NP_579917 NM_133340 NP_579918 NM_133341 NP_579919 NM_133342 NP_579920 NM_133343 NP_579921 NM_133344 NP_579922
Function	Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10232579, ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12400013}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Tissue Specificity	Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:10232579, ECO:0000269|PubMed:10480350, ECO:0000269|PubMed:11602352, ECO:0000269|PubMed:9660800}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Rad17 (phospho S635) peptide - ab28625 from Abcam Category Peptide

Human Rad17 (unmodified ) peptide - ab28626 from Abcam Category Peptide

Human Rad17 full length protein - ab159301 from Abcam Category Protein Source Wheat germ Species Human

Human Rad17 protein fragment - ab159302 from Abcam Category Protein Source Wheat germ Species Human

RAD17 Antibody Blocking Peptide - LS-E1164 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAD17 Antibody Blocking Peptide - LS-E10523 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAD17 Antibody Blocking Peptide - LS-E10624 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Rad17 Protein - H00005884-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Rad17 Protein - H00005884-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

RAD17-Antibody-Center-Blocking-peptide - BP11700c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAD17 Blocking Peptide - 33R-7392 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAD17 Blocking Peptide - 33R-10779 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

RAD17 Blocking Peptide - 33R-6262 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAD17 - H00005884-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

RAD17 - H00005884-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAD17 - H00005884-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAD17 fusion protein - Ag4171 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RAD17 fusion protein - Ag4348 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human RAD17, GST-tagged - RAD17-2152H from Creative Biomart Category Protein Source E.coli Species Human

Rad17 (A639) Peptide - BS1421P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-Rad17 (S645) Peptide - BS4248P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Cell cycle checkpoint protein RAD17(RAD17) - CSB-YP019253HU CSB-EP019253HU CSB-BP019253HU CSB-MP019253HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Rad17 Blocking Peptide - 3484RBP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

Rad17 (371-670) - sc-4427 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

RAD17 Blocking Peptide - CBP4189 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

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