RAD17

Gene Symbol RAD17
Entrez Gene 5884
Alt Symbol CCYC, HRAD17, R24L, RAD17SP, RAD24
Species Human
Gene Type protein-coding
Description RAD17 homolog (S. pombe)
Other Description RAD1 homolog|RF-C activator 1 homolog|RF-C/activator 1 homolog|Rad17-like protein|cell cycle checkpoint protein (RAD17)|cell cycle checkpoint protein RAD17
Swissprots Q7Z3S4 Q9UNR7 O75714 Q9UPF5 O75943 D3DWA5 A8K8X2 Q9UNK7 Q9UNR8
Accessions AAD42176 AAT09763 CAB46364 EAW51279 EAW51280 EAW51281 EAW51282 EAW51283 EAW51284 EAW51285 EAW51286 EAW51287 EAW51288 EAW51289 O75943 AF017748 AAD01620 AF076838 AAC95520 AF085736 AAC36334 AF098533 AAC97950 AF098534 AAC97951 AF112263 AAD38878 AF126424 AAD17334 AJ001642 CAA04894 AJ004977 CAA06251 AK292487 BAF85176 AL122068 CAB59244 AM393045 CAL37923 BC018110 BC032304 AAH32304 BX537441 CAD97683 DQ891608 ABM82534 DQ894801 ABM85727 XM_005276774 XP_005276831 XM_011546954 XP_011545256 XM_011546955 XP_011545257 NM_001278622 NP_001265551 NM_002873 NP_002864 NM_133338 NP_579916 NM_133339 NP_579917 NM_133340 NP_579918 NM_133341 NP_579919 NM_133342 NP_579920 NM_133343 NP_579921 NM_133344 NP_579922
Function Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10232579, ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12400013}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Tissue Specificity Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:10232579, ECO:0000269|PubMed:10480350, ECO:0000269|PubMed:11602352, ECO:0000269|PubMed:9660800}.

Rad17 CRISPR/Cas9 KO Plasmid (h) - sc-401681 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad17 HDR Plasmid (h) - sc-401681-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad17 Double Nickase Plasmid (h) - sc-401681-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad17 Double Nickase Plasmid (h2) - sc-401681-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad17 CRISPR Activation Plasmid (h) - sc-401681-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad17 CRISPR Activation Plasmid (h2) - sc-401681-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad17 Lentiviral Activation Particles (h) - sc-401681-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad17 Lentiviral Activation Particles (h2) - sc-401681-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad17 siRNA (h) - sc-36358 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rad17 shRNA Plasmid (h) - sc-36358-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rad17 shRNA (h) Lentiviral Particles - sc-36358-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rad17 RNAi - H00005884-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Rad17 RNAi - H00005884-R07 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Rad17 RNAi - H00005884-R08 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

Rad17 RNAi - H00005884-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

Rad17 RNAi - H00005884-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Rad17 RNAi - H00005884-R06 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU114231 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17891 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17891 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12180 from Sigma-Aldrich

Category miRNA

RAD17 siRNA (Human) - CRH3973 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Rad17 RNAi - H00005884-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Rad17 RNAi - H00005884-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RAD17 - MBS8221961 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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