HORMAD1

Gene Symbol HORMAD1
Entrez Gene 84072
Alt Symbol CT46, NOHMA
Species Human
Gene Type protein-coding
Description HORMA domain containing 1
Other Description HORMA domain-containing protein 1|cancer/testis antigen 46|newborn ovary HORMA protein
Swissprots Q5T5I3 Q86X24 Q4G114 Q6FIC1 Q5T5I5 Q5T5I4 B3KUK1 A6NMK2 Q9H0K8
Accessions CBH30631 EAW53520 EAW53521 EAW53522 EAW53523 EAW53524 EAW53525 Q86X24 AA991355 AK097390 BAG53463 AK098633 AL136755 CAB66689 AM392561 CAL37439 AM392979 CAL37857 AY626344 AAT45740 BC033014 AAH33014 BC047406 AAH47406 BU570274 CR533505 CAG38536 XM_006711569 XP_006711632 XM_006711570 XP_006711633 XM_006711571 XP_006711634 XM_011510053 XP_011508355 XM_011510054 XP_011508356 XM_011510055 XP_011508357 XM_011510056 XP_011508358 NM_001199829 NP_001186758 NM_032132 NP_115508
Function Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250}.
Tissue Specificity Testis-specific. Over-expressed in carcinomas. {ECO:0000269|PubMed:15999985}.

HORMAD1 (C-17) - sc-82188 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HORMAD1 (C-17): sc-82188. Western blot analysis of HORMAD1 expression in Hs 181 Tes whole cell lysate (A) and human cerebellum tissue extract (B).

HORMAD1 (V-15) - sc-82191 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HORMAD1 (V-15): sc-82191. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in seminiferous ducts.

HORMAD1 (GG-Y) - sc-101235 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
HORMAD1 (GG-Y): sc-101235. Western blot analysis of HORMAD1 expression in Hep G2 whole cell lysate.

Anti-HORMAD1 antibody - ab57883 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing JEG3 cells stained with ab57883 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab57883, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-HORMAD1 antibody - ab155176 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HORMAD1 antibody (ab155176) at 1/1000 dilution + mouse testis whole cell lysate at 50 µg

Anti-HORMAD1 antibody - ab138441 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-HORMAD1 antibody (ab138441) at 1/100 dilution + 293 cell line lysates at 35 µg

Anti-HORMAD1 antibody [EPR10273] - C-terminal - ab178432 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10273
All lanes : Anti-HORMAD1 antibody [EPR10273] - C-terminal (ab178432) at 1/1000 dilutionLane 1 : HepG2 cell line lysateLane 2 : HUVEC cell line lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP conjugated antibodydeveloped using the ECL technique

Anti-HORMAD1 Antibody (aa161-189, FITC) - LS-C258738 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HORMAD1 Antibody (aa161-189, Biotin) - LS-C258737 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HORMAD1 Antibody (aa161-189, AP) - LS-C258735 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HORMAD1 Antibody (aa1-395, clone 10D196, Azide-free) - LS-C183689 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10D196

Anti-HORMAD1 Antibody (aa161-189, APC) - LS-C258736 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HORMAD1 Antibody (aa161-189, Azide-free, HRP) - LS-C258739 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HORMAD1 Antibody (aa161-189, PE) - LS-C258740 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HORMAD1 Antibody - LS-C155598 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: NT2D1 12% SDS PAGE HORMAD1 antibody diluted at 1:1000

Anti-HORMAD1 Antibody - LS-C308286 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-HORMAD1 Antibody (aa160-189) - LS-C322032 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HORMAD1 Antibody (aa161-189) - LS-C159861 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HORMAD1 Antibody western blot of 293 cell line lysates (35 ug/lane). The HORMAD1 antibody detected the HORMAD1 protein (arrow).

Anti-HORMAD1 Antibody (aa321-370) - LS-C119126 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa/HUVEC/COLO cells, using HORMAD1 Antibody. The lane on the right is treated with the synthesized peptide.

HORMAD1 Antibody - NBP1-85401 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: HORMAD1 Antibody [NBP1-85401] - Staining of human testis shows strong nuclear positivity in cells in seminiferus ducts.

HORMAD1 Antibody (2E5) - H00084072-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E5
Western Blot: HORMAD1 Antibody (2E5) [H00084072-M01] - HORMAD1 monoclonal antibody (M01), clone 2E5 Analysis of HORMAD1 expression in HepG2.

HORMAD1 Antibody - NBP2-16870 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: HORMAD1 Antibody [NBP2-16870] - Sample (30 ug of whole cell lysate) A: NT2D1 12% SDS PAGE gel, diluted at 1:1000.

Anti-HORMAD1, C-Terminal antibody produced in rabbit - SAB4503318 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HORMAD1, C-Terminal: <B>Cat. No. SAB4503318</B>: Immunoblotting analysis of extracts from HeLa/HuvEc/COLO cells, using Anti-HORMAD1, C-Terminal antibody. The lane on the left was treated with the Anti-HORMAD1, C-Terminal antibody. The lane on the right (negative control) was treated with both Anti-HORMAD1, C-Terminal antibody and the synthesized immunogen peptide.

Anti-HORMAD1 antibody produced in rabbit - HPA037850 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HORMAD1: <B>Cat. No. HPA037850</B>: Immunohistochemical staining of human testis shows strong nuclear positivity in cells in seminiferus ducts.

Monoclonal Anti-HORMAD1 antibody produced in mouse - WH0084072M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E5
<B>Immunoblotting</B><BR/>Monoclonal Anti-HORMAD1, <B>Cat. No. WH0084072M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~45.2 kDa using HepG2 lysate.
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