HORMAD1
| Gene Symbol | HORMAD1 |
|---|---|
| Entrez Gene | 84072 |
| Alt Symbol | CT46, NOHMA |
| Species | Human |
| Gene Type | protein-coding |
| Description | HORMA domain containing 1 |
| Other Description | HORMA domain-containing protein 1|cancer/testis antigen 46|newborn ovary HORMA protein |
| Swissprots | Q5T5I3 Q86X24 Q4G114 Q6FIC1 Q5T5I5 Q5T5I4 B3KUK1 A6NMK2 Q9H0K8 |
| Accessions | CBH30631 EAW53520 EAW53521 EAW53522 EAW53523 EAW53524 EAW53525 Q86X24 AA991355 AK097390 BAG53463 AK098633 AL136755 CAB66689 AM392561 CAL37439 AM392979 CAL37857 AY626344 AAT45740 BC033014 AAH33014 BC047406 AAH47406 BU570274 CR533505 CAG38536 XM_006711569 XP_006711632 XM_006711570 XP_006711633 XM_006711571 XP_006711634 XM_011510053 XP_011508355 XM_011510054 XP_011508356 XM_011510055 XP_011508357 XM_011510056 XP_011508358 NM_001199829 NP_001186758 NM_032132 NP_115508 |
| Function | Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250}. |
| Tissue Specificity | Testis-specific. Over-expressed in carcinomas. {ECO:0000269|PubMed:15999985}. |
HORMAD1 CRISPR/Cas9 KO Plasmid (h) - sc-409128 from Santa Cruz Biotechnology
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HORMAD1 HDR Plasmid (h) - sc-409128-HDR from Santa Cruz Biotechnology
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HORMAD1 Double Nickase Plasmid (h) - sc-409128-NIC from Santa Cruz Biotechnology
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HORMAD1 Double Nickase Plasmid (h2) - sc-409128-NIC-2 from Santa Cruz Biotechnology
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HORMAD1 CRISPR Activation Plasmid (h) - sc-409128-ACT from Santa Cruz Biotechnology
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HORMAD1 CRISPR Activation Plasmid (h2) - sc-409128-ACT-2 from Santa Cruz Biotechnology
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HORMAD1 Lentiviral Activation Particles (h) - sc-409128-LAC from Santa Cruz Biotechnology
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HORMAD1 Lentiviral Activation Particles (h2) - sc-409128-LAC-2 from Santa Cruz Biotechnology
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HORMAD1 siRNA (h) - sc-75273 from Santa Cruz Biotechnology
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HORMAD1 shRNA Plasmid (h) - sc-75273-SH from Santa Cruz Biotechnology
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HORMAD1 shRNA (h) Lentiviral Particles - sc-75273-V from Santa Cruz Biotechnology
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HORMAD1 RNAi - H00084072-R01 from Novus Biologicals
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MISSION® esiRNA - EHU112871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10225 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10225 from Sigma-Aldrich
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HORMAD1 siRNA (Human) - CRJ3285 from Cohesion Biosciences
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HORMAD1 - MBS8219710 from MyBioSource
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shRNA set against Human HORMAD1 (NM_032132.4) - SHH314045 from Creative biogene
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Human HORMAD1 siRNA - orb273786 from Biorbyt
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HORMAD1 shRNA Plasmid (Human) - CHJ3285 from Cohesion Biosciences
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HORMAD1 miRNA 3'UTR clone - MiUTR3H-10822 from Creative biogene
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