| Gene Symbol |
DHRS9
|
| Entrez Gene |
10170
|
| Alt Symbol |
3-alpha-HSD, 3ALPHA-HSD, RDH-E2, RDH-TBE, RDH15, RDHL, RDHTBE, RETSDR8, SDR9C4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dehydrogenase/reductase (SDR family) member 9
|
| Other Description |
3-alpha hydroxysteroid dehydrogenase|NADP-dependent retinol dehydrogenase/reductase|dehydrogenase/reductase SDR family member 9|retinol dehydrogenase 15|retinol dehydrogenase homolog|short chain dehydrogenase/reductase family 9C member 4|short chain dehydrogenase/reductase family 9C, member 4|short-chain dehydrogenase/reductase retSDR8|tracheobronchial epithelial cell-specific retinol dehydrogenase
|
| Swissprots |
D3DPC1 Q9NRB0 Q9NRA9 Q5RKX1 B7Z416 Q9BPW9
|
| Accessions |
AAX88964 AAY24306 EAX11282 EAX11283 EAX11284 Q9BPW9 AF067174 AAD32458 AF240697 AAF82747 AF240698 AAF82748 AF295380 AAL37037 AF343729 AAK37528 AF529286 AAN04008 AF529287 AAN04009 AF529288 AAN04010 AK296625 BAH12402 AK313220 BAG36032 AY017349 AAG49422 AY359046 AAQ89405 BC040380 BC051797 BC058883 AAH58883 CA307349 DB010228 GQ129414 ACT64548 GQ129415 ACT64549 HQ448109 ADQ32590 XM_011510475 XP_011508777 XM_011510476 XP_011508778 NM_001142270 NP_001135742 NM_001142271 NP_001135743 NM_001289763 NP_001276692 NM_199204 NP_954674 NM_005771
|
| Function |
3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. {ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084}.
|
| Subcellular Location |
Microsome membrane {ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084}. Endoplasmic reticulum membrane {ECO:0000305}. Note=Associated with microsomal membranes.
|
| Tissue Specificity |
Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node. {ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084}.
|
| Top Pathways |
Retinol metabolism
|