| Gene Symbol |
TAAR1
|
| Entrez Gene |
134864
|
| Alt Symbol |
TA1, TAR1, TRAR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
trace amine associated receptor 1
|
| Other Description |
taR-1|trace amine receptor 1|trace amine-associated receptor 1
|
| Swissprots |
Q5VUQ1 Q96RJ0 Q2M1W5 Q3MIH8
|
| Accessions |
AAG17112 AAK71236 EAW48021 Q96RJ0 AY180374 AAO22154 BC101825 AAI01826 BC112194 AAI12195 NM_138327 NP_612200
|
| Function |
Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. {ECO:0000269|PubMed:15718104}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|