Gene Symbol | IL17RA |
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Entrez Gene | 23765 |
Alt Symbol | CANDF5, CD217, CDw217, IL-17RA, IL17R, hIL-17R |
Species | Human |
Gene Type | protein-coding |
Description | interleukin 17 receptor A |
Other Description | IL-17 receptor A|interleukin-17 receptor A |
Swissprots | O43844 Q20WK1 Q96F46 |
Accessions | CAL44890 CAV28582 CCB07364 EAW57738 EAW57739 EAW57740 EAW57741 Q96F46 AF021799 AK056836 AK093772 BC011624 AAH11624 BC012071 BE242733 BU585070 BX334547 BX368715 BX410574 CB044543 CT841520 CAJ86450 DQ891962 ABM82888 DQ895152 ABM86078 JF305973 ADY18334 U58917 AAB99730 NM_001289905 NP_001276834 NM_014339 NP_055154 |
Function | Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. {ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21993848}. |
Subcellular Location | Isoform 1: Membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:21993848}. |
Top Pathways | Cytokine-cytokine receptor interaction |
IL-17RA CRISPR/Cas9 KO Plasmid (h) - sc-401447 from Santa Cruz Biotechnology
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IL-17RA HDR Plasmid (h) - sc-401447-HDR from Santa Cruz Biotechnology
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IL-17RA Double Nickase Plasmid (h) - sc-401447-NIC from Santa Cruz Biotechnology
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IL-17RA Double Nickase Plasmid (h2) - sc-401447-NIC-2 from Santa Cruz Biotechnology
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IL-17RA CRISPR Activation Plasmid (h) - sc-401447-ACT from Santa Cruz Biotechnology
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IL-17RA CRISPR Activation Plasmid (h2) - sc-401447-ACT-2 from Santa Cruz Biotechnology
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IL-17RA Lentiviral Activation Particles (h) - sc-401447-LAC from Santa Cruz Biotechnology
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IL-17RA Lentiviral Activation Particles (h2) - sc-401447-LAC-2 from Santa Cruz Biotechnology
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IL-17R siRNA (h) - sc-40037 from Santa Cruz Biotechnology
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IL-17R shRNA Plasmid (h) - sc-40037-SH from Santa Cruz Biotechnology
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IL-17R shRNA (h) Lentiviral Particles - sc-40037-V from Santa Cruz Biotechnology
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IL-17 RA/IL-17 R RNAi - H00023765-R02 from Novus Biologicals
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MISSION® esiRNA - EHU136141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10580 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10580 from Sigma-Aldrich
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IL17RA siRNA (Human) - CRH8454 from Cohesion Biosciences
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IL17RA - MBS8212043 from MyBioSource
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shRNA set against Human IL17RA (NM_014339.5) - SHH318353 from Creative biogene
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IL17RA shRNA Plasmid (Human) - CHH8454 from Cohesion Biosciences
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IL17RA miRNA 3'UTR clone - MiUTR3H-07694 from Creative biogene
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