| Gene Symbol |
NCBP2
|
| Entrez Gene |
22916
|
| Alt Symbol |
CBC2, CBP20, NIP1, PIG55
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear cap binding protein subunit 2, 20kDa
|
| Other Description |
20 kDa nuclear cap-binding protein|NCBP 20 kDa subunit|NCBP interacting protein 1|NCBP-interacting protein 1|cell proliferation-inducing gene 55 protein|nuclear cap binding protein subunit 2, 20kD|nuclear cap-binding protein subunit 2
|
| Swissprots |
B2RE91 B4DMK7 Q14924 P52298 Q2TS50 E9PAR5
|
| Accessions |
EAW53620 EAW53621 EAW53622 EAW53623 EAW53624 P52298 AK093216 BAG52672 AK296144 BAG58884 AK297506 BAG59919 AK308192 AK315903 BAH14274 AK316601 BAG38188 AL110262 AW440347 AY644767 AAV85455 BC001255 AAH01255 BP248419 BT006842 AAP35488 BX537372 CAD97614 BX647994 CN421262 D59253 BAA09599 DC375323 DQ890703 ABM81629 DQ893887 ABM84813 X84157 CAA58962 XM_005269313 XP_005269370 XM_011512556 XP_011510858 XM_011512557 XP_011510859 XM_011512558 XP_011510860 NM_001042540 NP_001036005 NM_001308036 NP_001294965 NM_007362 NP_031388
|
| Function |
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC com
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:8601613}. Cytoplasm {ECO:0000269|PubMed:8601613}.
|
| Top Pathways |
Spliceosome, RNA transport, mRNA surveillance pathway
|