CUL7

Gene Symbol CUL7
Entrez Gene 9820
Alt Symbol 3M1, KIAA0076, dJ20C7.5
Species Human
Gene Type protein-coding
Description cullin 7
Other Description CUL-7|cullin-7
Swissprots B4DYZ0 Q5T654 F5H0L1 Q14999
Accessions CCQ43460 EAX04144 EAX04145 Q14999 AK292806 BAF85495 AK302668 BAG63902 AK307936 AK309902 BC033647 AAH33647 BG424177 D38548 BAA07551 DA496861 XM_005249503 XP_005249560 XM_006715285 XP_006715348 XM_011515019 XP_011513321 XM_011515020 XP_011513322 XM_011515021 XP_011513323 NM_001168370 NP_001161842 NM_014780 NP_055595
Function Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745)
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus (PubMed:24793695). CCDC8 is required for centrosomal location (PubMed:24793695). {ECO:0000269|PubMed:24793695}.
Tissue Specificity Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts. {ECO:0000269|PubMed:16142236}.
Top Pathways Ubiquitin mediated proteolysis

CUL-7 (AB13) - sc-53809 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUL-7 (AB13): sc-53809. Western blot analysis of CUL-7 expression in U-2 OS (A) and T98G (B) whole cell lysates.

CUL-7 (AB38) - sc-53810 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUL-7 (AB38): sc-53810. Western blot analysis of CUL-7 expression in U-2 OS (A) and T98G (B) whole cell lysates.

CUL-7 (H-58) - sc-134565 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CUL-7 (C-15) - sc-48461 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CUL-7 (C-15): sc-48461. Western blot analysis of CUL-7 expression in NIH/3T3 whole cell lysate.

CUL-7 (C-17) - sc-48462 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CUL-7 (C-17): sc-48462. Western blot analysis of CUL-7 expression in NIH/3T3 whole cell lysate.

CUL-7 (N-17) - sc-48464 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CUL-7 (N-13) - sc-48463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CUL-7 (N-13): sc-48463. Western blot analysis of CUL-7 expression in NIH/3T3 whole cell lysate.

Anti-Cullin 7 antibody - ab34841 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Cullin 7 antibody - ab96861 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Cullin 7 antibody (ab96861) at 1/1000 dilution + Molt-4 cell lysate at 30 µg

Anti-Cullin 7 antibody [Ab38] - ab53274 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone Ab38

Anti-Cullin 7 antibody - C-terminal - ab135041 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Cullin 7 antibody - C-terminal (ab135041) at 1/1000 dilution + A431 total cell extracts

Anti-CUL7 Antibody (aa1370-1698) - LS-C186334 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded U87 xenograft using Cullin 7 antibody at 1:100 dilution.

Anti-CUL7 Antibody (C-Terminus) - LS-C63994 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CUL7 Antibody (aa1681-1697) - LS-C90304 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CUL7 Antibody (C-Terminus) - LS-C128434 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CUL7 Antibody (aa1500-1550) - LS-C287138 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CUL7 Antibody (C-Terminus) - LS-C287139 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CUL7 Antibody (aa1-100) - LS-C307131 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CUL7 Antibody (C-Terminus) - LS-C287320 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse Cul7 by Immunoprecipitation. Samples: Whole cell lysate (1 mg) from human U2OS (H) and mouse wild-type MEF (M) cells. Antibody: Affinity purified rabbit anti-Cul7 antibody used at 3 ug/mg lysate for IP. Western blot of immunoprecipitates was performed using rabbit anti-Cul7 antibody at 0.33 ug/ml. Detection: Chemiluminescence with an exposure time of 15 seconds.

Anti-CUL7 Antibody (C-Terminus) IHC-plus™ - LS-B362 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CUL7 / Cullin 7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B362 dilution 1:500.

Cullin-7 Antibody - NBP1-85193 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Cullin-7 Antibody [NBP1-85193] - Staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.

Cullin-7 Antibody - NBP1-78042 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Cullin-7 Antibody [NBP1-78042] - Anti-Cullin-7 antibody was diluted 1:500 to detect Cullin-7 in human brain cortex tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required.

Cullin-7 Antibody - NB100-602 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: Cullin-7 Antibody [NB100-602] - Detection of Human and Mouse Cul7 by Samples: Whole cell lysate (1 mg) from human U2OS (H) and mouse wild-type MEF (M) cells. Western blot of immunoprecipitates was performed using another rabbit anti-Cul7 antibody. Detection: Chemiluminescence with an exposure time of 15 seconds.

Cullin-7 Antibody - NBP1-85194 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Cullin-7 Antibody [NBP1-85194] - Staining of human skeletal muscle shows strong cytoplasmic positivity.

Cullin-7 Antibody - 25170002 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: Cullin-7 Antibody [25170002]
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