| Gene Symbol |
CUL7
|
| Entrez Gene |
9820
|
| Alt Symbol |
3M1, KIAA0076, dJ20C7.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cullin 7
|
| Other Description |
CUL-7|cullin-7
|
| Swissprots |
B4DYZ0 Q5T654 F5H0L1 Q14999
|
| Accessions |
CCQ43460 EAX04144 EAX04145 Q14999 AK292806 BAF85495 AK302668 BAG63902 AK307936 AK309902 BC033647 AAH33647 BG424177 D38548 BAA07551 DA496861 XM_005249503 XP_005249560 XM_006715285 XP_006715348 XM_011515019 XP_011513321 XM_011515020 XP_011513322 XM_011515021 XP_011513323 NM_001168370 NP_001161842 NM_014780 NP_055595
|
| Function |
Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745)
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus (PubMed:24793695). CCDC8 is required for centrosomal location (PubMed:24793695). {ECO:0000269|PubMed:24793695}.
|
| Tissue Specificity |
Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts. {ECO:0000269|PubMed:16142236}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|