CUL7

Gene Symbol CUL7
Entrez Gene 9820
Alt Symbol 3M1, KIAA0076, dJ20C7.5
Species Human
Gene Type protein-coding
Description cullin 7
Other Description CUL-7|cullin-7
Swissprots B4DYZ0 Q5T654 F5H0L1 Q14999
Accessions CCQ43460 EAX04144 EAX04145 Q14999 AK292806 BAF85495 AK302668 BAG63902 AK307936 AK309902 BC033647 AAH33647 BG424177 D38548 BAA07551 DA496861 XM_005249503 XP_005249560 XM_006715285 XP_006715348 XM_011515019 XP_011513321 XM_011515020 XP_011513322 XM_011515021 XP_011513323 NM_001168370 NP_001161842 NM_014780 NP_055595
Function Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745)
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus (PubMed:24793695). CCDC8 is required for centrosomal location (PubMed:24793695). {ECO:0000269|PubMed:24793695}.
Tissue Specificity Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts. {ECO:0000269|PubMed:16142236}.
Top Pathways Ubiquitin mediated proteolysis

Human Cullin 7 protein fragment - ab153019 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153019 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human Cullin-7 Protein - H00009820-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Cullin-7 - H00009820-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Cullin-7 - H00009820-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CUL7 fusion protein - ag6943 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

CUL7 fusion protein - ag4675 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human Cullin-7(CUL7) ,partial - CSB-YP617942HU CSB-EP617942HU CSB-BP617942HU CSB-MP617942HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Cullin-7 Recombinant Protein Antigen - NBP1-85194PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Cullin-7 Recombinant Protein Antigen - NBP1-85193PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CUL7 Peptide, Human - M34GP03844H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Cullin-7 (1271-1279) - ta-053 from Creative Peptides

Category Peptide
Source Homo sapiens (human)

Cullin-7 (1271-1279) - ta-054 from Creative Peptides

Category Peptide
Source Homo sapiens (human)

Cullin-7 (915-923) - ta-081 from Creative Peptides

Category Peptide
Source Homo sapiens (human)

Cullin-7 (CUL7), partial, Recombinant Protein - MBS1398116 from MyBioSource

Category Protein
Prices $1,090.00, $1,090.00, $1,320.00, $1,320.00, $1,685.00, $1,685.00, $2,145.00, $2,145.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
Search more