MSH2

Gene Symbol	MSH2
Entrez Gene	4436
Alt Symbol	COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Species	Human
Gene Type	protein-coding
Description	mutS homolog 2
Other Description	DNA mismatch repair protein Msh2|hMSH2|mutS homolog 2, colon cancer, nonpolyposis type 1
Swissprots	O75488 P43246 B4E2Z2
Accessions	AAA82080 AAC27930 AAD14821 AAQ23475 AAS99351 AAY15096 ABQ45882 ABQ45885 ABQ45886 EAX00213 EAX00214 EAX00215 P43246 AK222860 BAD96580 AK223284 BAD97004 AK296831 BAG59401 AK297763 BAG60111 AK299667 BAG61581 AK304496 BAG65304 AK310679 AK311330 BC001122 BC012599 BC021566 AAH21566 BX649122 CB250419 DC342099 DQ648894 ABG49489 DQ648895 ABG49490 DQ648896 ABG49491 DQ648897 ABG49492 DQ892558 ABM83484 DQ895772 ABM86698 L47574 AAB59566 L47575 AAB59567 L47576 AAB59568 L47577 AAB59569 L47578 AAB59570 L47579 AAB59571 L47580 AAB59572 L47581 AAA76858 L47582 AAB59565 L47583 AAB59564 U03911 AAA18643 U04045 AAA61870 XM_005264332 XP_005264389 XM_011532867 XP_011531169 XR_939685 NM_000251 NP_000242 NM_001258281 NP_001245210
Function	Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformationa
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10856833}.
Top Pathways	Mismatch repair, Colorectal cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MSH2 ELISA Kit (Sandwich ELISA) - LS-F12083 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78-5000 pg/ml

Rabbit anti-MSH2 Antibody, Affinity Purified - PLA0106 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

DNA mismatch repair protein Msh2, MSH2, Human, ELISA Kit - E8706h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 78-5000 pg/mL

mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) , ELISA Kit - MBS9324250 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat MSH2 ELISA Kit (Custom ELISA) - LS-F20149 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Bovine MSH2 ELISA Kit (Custom ELISA) - LS-F20150 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Mouse MSH2 ELISA Kit (Custom ELISA) - LS-F20151 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

MSH2 - EKH4768 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

MSH2 ELISA Kit (Human) : 96 Wells (OKEH01843) - OKEH01843 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 32 pg/mL Range 78 - 5000 pg/mL

Human MSH2 ELISA Kit - E012151 from Biobool Category ELISA Kit Sensitivity <46.9pg/ml

Human DNA mismatch repair protein Msh2 ELISA Kit - EK4794 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Sensitivity less than 0.12ng/mL Range 0.312-20 ng/mL

anti-MSH2 antibody - ARG54160 from Arigo Biolaboratories Category ELISA Kit

anti-MSH2 antibody [SP46] - ARG53314 from Arigo Biolaboratories Category ELISA Kit

anti-MSH2 antibody - ARG53312 from Arigo Biolaboratories Category ELISA Kit

anti-MSH2 antibody [SP46] (Ready-to-Use) - ARG53315 from Arigo Biolaboratories Category ELISA Kit

anti-MSH2 antibody (Ready-to-Use) - ARG53313 from Arigo Biolaboratories Category ELISA Kit

DNA mismatch repair protein Msh2, ELISA Kit - MBS764440 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.9pg/ml Range 78-5000pg/ml

DNA mismatch repair protein Msh2, ELISA Kit - MBS9428620 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Sensitivity Less than 32pg/mL Range 78-5000 pg/mL

DNA mismatch repair protein Msh2, ELISA Kit - MBS2884756 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 78-5000 pg/mL

DNA mismatch repair protein Msh2, ELISA Kit - MBS285748 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human MSH2 ELISA Kit (Sandwich ELISA) - LS-F35503 from LifeSpan Bioscience Category ELISA Kit Sensitivity 46.9 Range 78-5000 pg/ml

Rat MSH2 ELISA Kit (CLIA) - LS-F37685 from LifeSpan Bioscience Category ELISA Kit Sensitivity 18.75 Range 78-5000 pg/ml

DNA Mismatch Repair Protein MSH2 (MSH2), ELISA Kit - MBS9399277 from MyBioSource Category ELISA Kit

DNA Mismatch Repair Protein MSH2 (MSH2), ELISA Kit - MBS9399285 from MyBioSource Category ELISA Kit

DNA Mismatch Repair Protein MSH2 (MSH2), ELISA Kit - MBS9399270 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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