MSH2

Gene Symbol	MSH2
Entrez Gene	4436
Alt Symbol	COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Species	Human
Gene Type	protein-coding
Description	mutS homolog 2
Other Description	DNA mismatch repair protein Msh2|hMSH2|mutS homolog 2, colon cancer, nonpolyposis type 1
Swissprots	O75488 P43246 B4E2Z2
Accessions	AAA82080 AAC27930 AAD14821 AAQ23475 AAS99351 AAY15096 ABQ45882 ABQ45885 ABQ45886 EAX00213 EAX00214 EAX00215 P43246 AK222860 BAD96580 AK223284 BAD97004 AK296831 BAG59401 AK297763 BAG60111 AK299667 BAG61581 AK304496 BAG65304 AK310679 AK311330 BC001122 BC012599 BC021566 AAH21566 BX649122 CB250419 DC342099 DQ648894 ABG49489 DQ648895 ABG49490 DQ648896 ABG49491 DQ648897 ABG49492 DQ892558 ABM83484 DQ895772 ABM86698 L47574 AAB59566 L47575 AAB59567 L47576 AAB59568 L47577 AAB59569 L47578 AAB59570 L47579 AAB59571 L47580 AAB59572 L47581 AAA76858 L47582 AAB59565 L47583 AAB59564 U03911 AAA18643 U04045 AAA61870 XM_005264332 XP_005264389 XM_011532867 XP_011531169 XR_939685 NM_000251 NP_000242 NM_001258281 NP_001245210
Function	Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformationa
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10856833}.
Top Pathways	Mismatch repair, Colorectal cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MSH2 full length protein - ab114351 from Abcam Category Protein Source Wheat germ Species Human

Human MSH2 protein fragment - ab114352 from Abcam Category Protein Source Wheat germ Species Human

MSH2 Antibody Blocking Peptide - LS-E1079 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MSH2 Antibody Blocking Peptide - LS-E15212 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MSH2 Antibody Blocking Peptide - LS-E15213 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MSH2 Protein - H00004436-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MSH2 Protein - H00004436-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MSH2-Antibody-Center-Blocking-peptide - BP11570c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MSH2 (His Tag) protein - orb232332 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Species Human

MSH2 peptide - orb72991 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

MSH2 Blocking Peptide - 33R-4562 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MSH2 Blocking Peptide - 33R-3449 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MSH2 - H00004436-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MSH2 - H00004436-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MSH2 - H00004436-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MSH2 - H00004436-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MSH2 fusion protein - ag7835 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MSH2 fusion protein - Ag17731 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MSH2 Peptide - 350528 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

MSH2 Human - GWB-E3B1F0 from Genway Biotech Category Protein Prices $75.00, $165.00, $1,195.00 Sizes 10 μg, 50 μg, 1000 μg Species Human

Recombinant Human MSH2 - MSH2-162H from Creative Biomart Category Protein Source Recombinant Human MSH2 protein encodingamino acids 735-934 expressed in E.coli.

Recombinant Human MSH2 - MSH2-28175TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human MSH2 - MSH2-28793TH from Creative Biomart Category Protein Source Wheat germ

Human MSH2 Protein (His & GST Tag) - 14425-H20B-20 from Sino Biological Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source Baculovirus-Insect Cells Species Human

Recombinant Human DNA mismatch repair protein Msh2(MSH2) ,partial - CSB-YP015028HU CSB-EP015028HU CSB-BP015028HU CSB-MP015028HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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