HES6

Gene Symbol HES6
Entrez Gene 55502
Alt Symbol C-HAIRY1, HES-6, bHLHb41, bHLHc23
Species Human
Gene Type protein-coding
Description hes family bHLH transcription factor 6
Other Description class B basic helix-loop-helix protein 41|hairy and enhancer of split 6|transcription cofactor HES-6
Swissprots Q96T93 B8ZZA9 Q53SN9 A8KAP6 Q8N2J2 Q9P2S3 Q96HZ4
Accessions AAY24337 CAI79369 EAW71149 EAW71150 EAW71151 EAW71152 Q96HZ4 AB035179 BAA96082 AF260237 AAK51634 AK075040 BAC11368 AK293111 BAF85800 BC007939 AAH07939 BE796220 DB495731 DT217800 NM_001142853 NP_001136325 NM_001282434 NP_001269363 NM_018645 NP_061115
Function Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000305}.

HES6 (D-20) - sc-13863 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HES6 (D-20): sc-13863. Western blot analysis of human recombinant HES6 fusion protein.

HES6 (F-5) - sc-133196 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HES6 (F-5): sc-133196. Western blot analysis of HES6 expression in non-transfected: sc-117752 (A) and mouse HES6 transfected: sc-120761 (B) 293T whole cell lysates.

HES6 (H-180) - sc-25396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HES6 (H-180): sc-25396. Western blot analysis of HES6 expression in mouse embryo tissue extract.

Anti-HES6 antibody - ab66461 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HES6 antibody - ab102823 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HES6 antibody (ab102823) at 1/100 dilution + MCF7 cell line lysate at 35 µg

Anti-HES6 antibody - ab172800 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-HES6 antibody (ab172800) at 1 µg/mlLane 1 : HES6 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-HES6 antibody - ab76982 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HES6 antibody (ab76982) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 4 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 5 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell LysateLane 6 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lane 7 : SHSY-5Y (Human neuroblastoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.Observed band size : 38 kDa (why is the actual band size different from the predicted?)Exposure time : 20 minutes

Anti-HES6 antibody [1D6] - ab139305 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D6
All lanes : Anti-HES6 antibody [1D6] (ab139305) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY HES6Lysates/proteins at 5 µg per lane.

Anti-HES6 Antibody (C-Terminus) - LS-C144770 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (C-Terminus) - LS-C153569 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (aa6-34, AP) - LS-C222723 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (aa1-50) - LS-C119209 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa cells, using HES6 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-HES6 Antibody (C-Terminus) - LS-C30622 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HES6 antibody LS-C30622 was used in IHC to stain formalin-fixed, paraffin-embedded human pancreas.

Anti-HES6 Antibody (aa6-34, APC) - LS-C222724 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (aa6-34, FITC) - LS-C222725 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (aa6-34, Biotin) - LS-C222726 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (aa6-34, Azide-free, HRP) - LS-C222727 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (aa6-34, PE) - LS-C222728 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (aa6-55) - LS-C292051 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody - LS-C308219 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HES6 Antibody (aa13-42) - LS-C321932 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (aa6-34) - LS-C166842 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of HES6 Antibody in MCF-7 cell line lysates (35 ug/lane). HES6 (arrow) was detected using the purified antibody.

Anti-HES6 Antibody (aa51-100) - LS-C169510 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HES6 Antibody (clone 1D6) - LS-C175448 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HES6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HES6.

Anti-HES6 Antibody (clone 2F7) - LS-C175461 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HES6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HES6.
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