| Gene Symbol |
HES6
|
| Entrez Gene |
55502
|
| Alt Symbol |
C-HAIRY1, HES-6, bHLHb41, bHLHc23
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hes family bHLH transcription factor 6
|
| Other Description |
class B basic helix-loop-helix protein 41|hairy and enhancer of split 6|transcription cofactor HES-6
|
| Swissprots |
Q96T93 B8ZZA9 Q53SN9 A8KAP6 Q8N2J2 Q9P2S3 Q96HZ4
|
| Accessions |
AAY24337 CAI79369 EAW71149 EAW71150 EAW71151 EAW71152 Q96HZ4 AB035179 BAA96082 AF260237 AAK51634 AK075040 BAC11368 AK293111 BAF85800 BC007939 AAH07939 BE796220 DB495731 DT217800 NM_001142853 NP_001136325 NM_001282434 NP_001269363 NM_018645 NP_061115
|
| Function |
Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
![Western Blot: HES6 Overexpression Lysate (Adult Normal) [NBL1-11513] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HES6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8614_HES6%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-11513-img0002.jpg)