Gene Symbol | HES6 |
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Entrez Gene | 55502 |
Alt Symbol | C-HAIRY1, HES-6, bHLHb41, bHLHc23 |
Species | Human |
Gene Type | protein-coding |
Description | hes family bHLH transcription factor 6 |
Other Description | class B basic helix-loop-helix protein 41|hairy and enhancer of split 6|transcription cofactor HES-6 |
Swissprots | Q96T93 B8ZZA9 Q53SN9 A8KAP6 Q8N2J2 Q9P2S3 Q96HZ4 |
Accessions | AAY24337 CAI79369 EAW71149 EAW71150 EAW71151 EAW71152 Q96HZ4 AB035179 BAA96082 AF260237 AAK51634 AK075040 BAC11368 AK293111 BAF85800 BC007939 AAH07939 BE796220 DB495731 DT217800 NM_001142853 NP_001136325 NM_001282434 NP_001269363 NM_018645 NP_061115 |
Function | Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
HES6 CRISPR/Cas9 KO Plasmid (h) - sc-404146 from Santa Cruz Biotechnology
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HES6 HDR Plasmid (h) - sc-404146-HDR from Santa Cruz Biotechnology
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HES6 Double Nickase Plasmid (h) - sc-404146-NIC from Santa Cruz Biotechnology
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HES6 Double Nickase Plasmid (h2) - sc-404146-NIC-2 from Santa Cruz Biotechnology
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HES6 CRISPR Activation Plasmid (h) - sc-404146-ACT from Santa Cruz Biotechnology
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HES6 CRISPR Activation Plasmid (h2) - sc-404146-ACT-2 from Santa Cruz Biotechnology
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HES6 Lentiviral Activation Particles (h) - sc-404146-LAC from Santa Cruz Biotechnology
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HES6 Lentiviral Activation Particles (h2) - sc-404146-LAC-2 from Santa Cruz Biotechnology
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HES6 siRNA (h) - sc-37109 from Santa Cruz Biotechnology
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HES6 shRNA Plasmid (h) - sc-37109-SH from Santa Cruz Biotechnology
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HES6 shRNA (h) Lentiviral Particles - sc-37109-V from Santa Cruz Biotechnology
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HES6 RNAi - H00055502-R01 from Novus Biologicals
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MISSION® esiRNA - EHU036431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9997 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9997 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05363 from Sigma-Aldrich
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HES6 siRNA (Human) - CRJ0711 from Cohesion Biosciences
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HES6 - MBS828022 from MyBioSource
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shRNA set against Human HES6 (NM_018645.4) - SHH311729 from Creative biogene
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Human HES6 siRNA - orb271212 from Biorbyt
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HES6 shRNA Plasmid (Human) - CHJ0711 from Cohesion Biosciences
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HES6 miRNA 3'UTR clone - MiUTR3H-11160 from Creative biogene
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HES6 miRNA 3'UTR clone - MiUTR3H-11161 from Creative biogene
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