Gene Symbol | AP3S2 |
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Entrez Gene | 10239 |
Alt Symbol | AP3S3, sigma3b |
Species | Human |
Gene Type | protein-coding |
Description | adaptor-related protein complex 3, sigma 2 subunit |
Other Description | AP-3 complex subunit sigma-2|AP-3 complex subunit sigma-3B|adapter-related protein complex 3 subunit sigma-2|adaptor complex sigma3B|adaptor-related protein complex 3 subunit sigma-2|clathrin-associated/assembly/adaptor protein, small 4, 22-kD|sigma-3B-adaptin|sigma-adaptin 3b |
Swissprots | Q53H83 B2R677 B4DGQ3 P59780 |
Accessions | EAX02071 EAX02072 EAX02073 EAX02074 EAX02075 P59780 AK222698 BAD96418 AK294712 BAG57864 AK312467 BAG35374 AL109702 AL110108 AW402906 BC002785 AAH02785 BC007773 AAH07773 BC010020 AAH10020 BC010615 BX098014 DA268327 DA337392 DA464242 DA752479 DA777624 DB322370 DC340463 DC410373 DQ892982 ABM83908 DQ896230 ABM87229 DR158459 X99459 CAA67824 NM_005829 NP_005820 NR_023361 NR_037582 |
Function | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
Subcellular Location | Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}. |
Tissue Specificity | Present in all adult tissues examined. {ECO:0000269|PubMed:9118953}. |
Top Pathways | Lysosome |
Anti-AP3S2 Antibody IHC-plus⢠- LS-B725 from LifeSpan Bioscience
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AP3S2 Antibody - NBP2-31897 from Novus Biologicals
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AP3S2 Antibody - NBP1-40318 from Novus Biologicals
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AP3S2 Antibody - H00010239-B01 from Novus Biologicals
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AP3S2 Antibody - H00010239-B01P from Novus Biologicals
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Anti-AP3S2 antibody produced in mouse - SAB1408744 from Sigma-Aldrich
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Anti-AP3S2 antibody produced in rabbit - HPA050067 from Sigma-Aldrich
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Anti-AP3S2 antibody produced in chicken - GW22217F from Sigma-Aldrich
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Anti-AP3S2 antibody produced in rabbit - HPA049270 from Sigma-Aldrich
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AP3S2 antibody - GTX82305 from GeneTex
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AP3S2 antibody - GTX85784 from GeneTex
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Anti -AP3S2 (AP-3 Complex Subunit sigma-2, AP-3 Complex Subunit sigma-3B, Adapter-relatedProtein Complex 3 sigma-2 Subunit, Sigma-3B-adaptin, Sigma3B-adaptin, Sigma-adaptin 3b) - A2298-54B from USBiological Life Science
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Anti -AP3S2 (Adapter-related Protein Complex 3 sigma-2 Subunit, AP3S3, Sigma3b) - 209532 from USBiological Life Science
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Anti -AP3s2 (Adaptor-related Protein Complex 3 sigma 2) - A2298-54 from USBiological Life Science
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AP3S2 antibody - 70R-15755 from Fitzgerald
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AP3S2 Polyclonal Antibody - A4389 from ABclonal
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AP3S2 Antibody - abx003271 from Abbexa
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AP3 complex subunit sigma-2 antibody - 15319-1-AP from Acris Antibodies
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AP3 complex subunit sigma-2 / AP3S2 (full length) antibody - AP09031AF-N from Acris Antibodies
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AP3 complex subunit sigma-2 antibody - H00010239-B01 from Acris Antibodies
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AP3 complex subunit sigma-2 antibody - H00010239-B01P from Acris Antibodies
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Chicken Anti-Human AP3S2 - 119-11803 from RayBiotech
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Anti-AP3S2, Polyclonal Antibody - 25-A4389 from ARP American Research Products
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AP3S2 Antibody - 49-596 from ProSci
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AP3S2 Antibody - XW-7991 from ProSci
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