RP2

Gene Symbol	RP2
Entrez Gene	6102
Alt Symbol	DELXp11.3, NM23-H10, NME10, TBCCD2, XRP2
Species	Human
Gene Type	protein-coding
Description	retinitis pigmentosa 2 (X-linked recessive)
Other Description	protein XRP2
Swissprots	Q9NU67 Q86XJ7 O75695
Accessions	EAW59275 O75695 AJ007590 CAA07577 AK312555 BAG35452 AL049366 BC027851 BC043348 AAH43348 BC053530 AAH53530 DA211161 HQ448604 ADQ33082 NM_006915 NP_008846
Function	Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. {ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:18376416, ECO:0000269|PubMed:20106869, ECO:0000269|PubMed:22085962}.
Subcellular Location	Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium. Note=Detected predominantly to the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus.
Tissue Specificity	Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level). {ECO:0000269|PubMed:10942419, ECO:0000269|PubMed:12417528, ECO:0000269|PubMed:18376416}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RP2-Over-expression-Lysate - LY10427a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

RP2 293T Cell Transient Overexpression Lysate(Denatured) - H00006102-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

RP2 overexpression lysate - LY416325 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RP2 293 Cell Lysate - 407634 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

RP2 Overexpression Lysate (Denatured) - H00006102-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

RP2 Overexpression Lysate (Native) - NBL1-15486 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RP2 (h): 293T Lysate - sc-115936 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RP2 Over-expression Lysate Product - GWB-E94780 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human XRP2 / RP2 Insect Cell Lysate (WB positive control) - 11092-H09BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human XRP2 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb174930 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human RP2 Knockdown Stable Cell Line - CSC-DC013477 from Creative biogene Category Cell Line Species Human

Search more