RP2

Gene Symbol	RP2
Entrez Gene	6102
Alt Symbol	DELXp11.3, NM23-H10, NME10, TBCCD2, XRP2
Species	Human
Gene Type	protein-coding
Description	retinitis pigmentosa 2 (X-linked recessive)
Other Description	protein XRP2
Swissprots	Q9NU67 Q86XJ7 O75695
Accessions	EAW59275 O75695 AJ007590 CAA07577 AK312555 BAG35452 AL049366 BC027851 BC043348 AAH43348 BC053530 AAH53530 DA211161 HQ448604 ADQ33082 NM_006915 NP_008846
Function	Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. {ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:18376416, ECO:0000269|PubMed:20106869, ECO:0000269|PubMed:22085962}.
Subcellular Location	Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium. Note=Detected predominantly to the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus.
Tissue Specificity	Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level). {ECO:0000269|PubMed:10942419, ECO:0000269|PubMed:12417528, ECO:0000269|PubMed:18376416}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RP2 full length protein - ab159371 from Abcam Category Protein Source Wheat germ Species Human

Human RP2 protein fragment - ab159372 from Abcam Category Protein Source Wheat germ Species Human

RP2 Antibody Blocking Peptide - LS-E20637 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RP2 Protein - H00006102-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RP2 Protein - H00006102-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Human XRP2 GST tag protein - orb83423 from Biorbyt Category Protein Prices $323.00, $1,224.00 Sizes 10 μg, 100 μg Source Insect Species Human

RP2 Blocking Peptide - 33R-4895 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RP2 - H00006102-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

RP2 - H00006102-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RP2 - H00006102-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RP2 fusion protein - Ag5332 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RP2 fusion protein - ag5630 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human RP2, GST tagged - RP2-2218H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human RP2, GST-tagged - RP2-2362H from Creative Biomart Category Protein Source E.coli Species Human

Human XRP2 / RP2 Protein (GST Tag) - 11092-H09B-10 from Sino Biological Category Protein Prices $138.00, $698.00 Sizes 10 µg, 100 µg Source Baculovirus-Insect Cells Species Human

Recombinant Human Protein XRP2(RP2) - CSB-YP020076HU CSB-EP020076HU CSB-BP020076HU CSB-MP020076HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RP2 Protein - abx164266 from Abbexa Category Protein Species Human, Mouse, Rat

RP2 - TP308124 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human XRP2 / RP2 Protein (GST tag) - PKSH031261 from Elabscience Category Protein Source Baculoviru Species Human

RP2 Peptide, Human - M34GP13477H from Creative Peptides Category Peptide Source Synthetic. Species Human

RP2 Antibody - SH-A15299 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

RP2 Recombinant Protein Antigen - NBP1-82549PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Human RP2 protein - orb54424 from Biorbyt Category Protein Prices $289.00, $408.00, $476.00, $765.00, $1,275.00, $2,023.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

Protein XRP2 (RP2), Recombinant Protein - MBS1238040 from MyBioSource Category Protein Prices $1,115.00, $1,115.00, $1,345.00, $1,345.00, $1,760.00, $1,760.00, $2,225.00, $2,225.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RP2 Recombinant Protein (Human) (OPCA04911) - OPCA04911 from Aviva Systems Biology Category Protein Species Human

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