RP2

Gene Symbol RP2
Entrez Gene 6102
Alt Symbol DELXp11.3, NM23-H10, NME10, TBCCD2, XRP2
Species Human
Gene Type protein-coding
Description retinitis pigmentosa 2 (X-linked recessive)
Other Description protein XRP2
Swissprots Q9NU67 Q86XJ7 O75695
Accessions EAW59275 O75695 AJ007590 CAA07577 AK312555 BAG35452 AL049366 BC027851 BC043348 AAH43348 BC053530 AAH53530 DA211161 HQ448604 ADQ33082 NM_006915 NP_008846
Function Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. {ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:18376416, ECO:0000269|PubMed:20106869, ECO:0000269|PubMed:22085962}.
Subcellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium. Note=Detected predominantly to the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus.
Tissue Specificity Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level). {ECO:0000269|PubMed:10942419, ECO:0000269|PubMed:12417528, ECO:0000269|PubMed:18376416}.

RP2 (C-9) - sc-390220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RP2 (C-9): sc-390220. Western blot analysis of RP2 expression in non-transfected: sc-117752 (A) and human RP2 transfected: sc-115936 (B) 293T whole cell lysates.

RP2 (D-20) - sc-79710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RP2 (H-209) - sc-366049 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RP2 (H-209): sc-366049. Western blot analysis of RP2 expression in non-transfected: sc-117752 (A) and human RP2 transfected: sc-115936 (B) 293T whole cell lysates.

RP2 (37.28) - sc-81892 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
RP2 (37.28): sc-81892. Western blot analysis of RP2 expression in non-transfected 293T: sc-117752 (A) and human RP2 transfected 293T: sc-115936 (B) whole cell lysates and HeLa nuclear extract (C).

Anti-RP2 antibody - ab98353 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RP2 antibody (ab98353) at 1 µg/ml + Human fetal muscle lysate at 10 µg

Anti-RP2 antibody - ab58315 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-RP2 antibody - ab172279 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RP2 antibody (ab172279) at 1 µg/mlLane 1 : RP2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-RP2 antibody [EPR11362] - ab174840 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11362
All lanes : Anti-RP2 antibody [EPR11362] (ab174840) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Sh-SY5Y cell lysateLysates/proteins at 10 µg per lane.

Anti-RP2 Antibody (aa251-351, Azide-free) - LS-C328574 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-RP2 Antibody - LS-C332427 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Jurkat cell line, using RP2 antibody.

Anti-RP2 Antibody (clone 1B4) - LS-C139400 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B4
RP2 monoclonal antibody (M01), clone 1B4. Western blot of RP2 expression in HeLa NE.

Anti-RP2 Antibody (C-Terminus) IHC-plus™ - LS-B6635 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RP2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6635 concentration 5 ug/ml.

RP2 Antibody - NBP1-56852 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RP2 Antibody [NBP1-56852] - Titration: 0.2-1 ug/ml, Positive Control: Human Muscle.

RP2 Antibody - NBP1-82550 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: RP2 Antibody [NBP1-82550] Staining of human cell line A-431 shows positivity in plasma membrane & cytoplasm.

RP2 Antibody - NBP1-82549 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RP2 Antibody [NBP1-82549] - ane 1: Marker [kDa] 219, 112, 85, 49, 32, 25, 18 Lane 2: Human cell line RT-4 Lane 3: Human cell line U-251MG sp Lane 4: Human cell line A-431

RP2 Antibody (5C10) - H00006102-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5C10
Western Blot: RP2 Antibody (5C10) [H00006102-M02] - RP2 monoclonal antibody (M02), clone 5C10 Analysis of RP2 expression in Hela S3 NE.

RP2 Antibody (1B4) - H00006102-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B4
Western Blot: RP2 Antibody (1B4) [H00006102-M01] - RP2 monoclonal antibody (M01), clone 1B4. Analysis of RP2 expression in Hela S3 NE.

RP2 Antibody - H00006102-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

RP2 Antibody - H00006102-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RP2 Antibody [H00006102-B01P] - Analysis of RP2 expression in human pancreas.

Monoclonal Anti-RP2 antibody produced in mouse - WH0006102M2 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5C10
<B>Immunoblotting</B><BR/>Monoclonal Anti-RP2, <B>Cat. No. WH0006102M2</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~39.6 kDa using Hela NE lysate.

Anti-RP2 antibody produced in rabbit - SAB1411201 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RP2: <B>Cat. No. SAB1411201</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~39.6 kDa using RP2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-RP2 antibody produced in mouse - SAB1406398 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RP2: <B>Cat. No. SAB1406398</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~39.4 kDa using human pancreas lysate.

Monoclonal Anti-RP2, (C-terminal) antibody produced in mouse - SAB1404326 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B4
<B>Immunoblotting</B><BR/>Monoclonal Anti-RP2: <B>Cat. No. SAB1404326</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~39.6 kDa using HeLa NE lysate.

Anti-RP2 antibody produced in rabbit - SAB2105045 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RP2: <B>Cat. No. SAB2105045</B>: Immunohistochemistry of RP2 in Brain, cerebellum tissue with RP2 antibody at 4-8 μg/mL.

RP2 antibody - middle region (ARP56724_P050) - ARP56724_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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