Gene Symbol | SLC38A2 |
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Entrez Gene | 54407 |
Alt Symbol | ATA2, PRO1068, SAT2, SNAT2 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 38, member 2 |
Other Description | amino acid transporter 2|amino acid transporter A2|protein 40-9-1|sodium-coupled neutral amino acid transporter 2|system A amino acid transporter 2|system A transporter 1|system N amino acid transporter 2 |
Swissprots | Q9NVA8 Q9P2G5 Q6ZMG2 Q6IA88 Q96QD8 Q9HAV3 |
Accessions | EAW57900 EAW57901 EAW57902 Q96QD8 AB037803 BAA92620 AF116620 AAF71044 AF259799 AAK38510 AF298897 AAG24618 AJ344099 CAC51434 AK001700 BAA91846 AK172784 BAD18765 AK291644 BAF84333 AK293858 BAG57253 BC016909 BC029379 AAH29379 BC040342 AAH40342 CR457267 CAG33548 DA725217 DQ891801 ABM82727 DQ894985 ABM85911 XM_005268983 XP_005269040 XR_944589 NM_001307936 NP_001294865 NM_018976 NP_061849 |
Function | Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. {ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15922329}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}; Multi-pass membrane protein {ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). {ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}. |
Top Pathways | Protein digestion and absorption, GABAergic synapse, Glutamatergic synapse |
SNAT2 (C-6) - sc-514037 from Santa Cruz Biotechnology
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SNAT2 (G-8) - sc-166366 from Santa Cruz Biotechnology
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SNAT2 (H-60) - sc-67081 from Santa Cruz Biotechnology
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SNAT2 (N-19) - sc-33442 from Santa Cruz Biotechnology
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SNAT2 (C-12) - sc-33444 from Santa Cruz Biotechnology
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Anti-SLC38A2 / SNAT2 Antibody (Trp190) - LS-C193254 from LifeSpan Bioscience
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Anti-SLC38A2 / SNAT2 Antibody (aa141-190) - LS-C200690 from LifeSpan Bioscience
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Anti-SLC38A2 / SNAT2 Antibody (N-Terminus) - LS-C31204 from LifeSpan Bioscience
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Anti-SLC38A2 / SNAT2 Antibody (aa151-200) - LS-C120499 from LifeSpan Bioscience
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Anti-SLC38A2 / SNAT2 Antibody - LS-C179270 from LifeSpan Bioscience
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Anti-SLC38A2 / SNAT2 Antibody (aa35-84) IHC-plus⢠- LS-B9654 from LifeSpan Bioscience
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SLC38A2 Antibody - NBP1-88872 from Novus Biologicals
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SLC38A2/SNAT2 Polyclonal Antibody - bs-12125R from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12125R-A350 from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12125R-A488 from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12125R-A555 from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12125R-A647 from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, Cy3 Conjugated - bs-12125R-Cy3 from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, Cy5 Conjugated - bs-12125R-Cy5 from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, Cy5.5 Conjugated - bs-12125R-Cy5.5 from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, Cy7 Conjugated - bs-12125R-Cy7 from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, FITC Conjugated - bs-12125R-FITC from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, Biotin Conjugated - bs-12125R-Biotin from Bioss
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SLC38A2/SNAT2 Polyclonal Antibody, HRP Conjugated - bs-12125R-HRP from Bioss
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Anti-SLC38A2 antibody produced in rabbit - SAB4502246 from Sigma-Aldrich
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