SLC38A2

Gene Symbol SLC38A2
Entrez Gene 54407
Alt Symbol ATA2, PRO1068, SAT2, SNAT2
Species Human
Gene Type protein-coding
Description solute carrier family 38, member 2
Other Description amino acid transporter 2|amino acid transporter A2|protein 40-9-1|sodium-coupled neutral amino acid transporter 2|system A amino acid transporter 2|system A transporter 1|system N amino acid transporter 2
Swissprots Q9NVA8 Q9P2G5 Q6ZMG2 Q6IA88 Q96QD8 Q9HAV3
Accessions EAW57900 EAW57901 EAW57902 Q96QD8 AB037803 BAA92620 AF116620 AAF71044 AF259799 AAK38510 AF298897 AAG24618 AJ344099 CAC51434 AK001700 BAA91846 AK172784 BAD18765 AK291644 BAF84333 AK293858 BAG57253 BC016909 BC029379 AAH29379 BC040342 AAH40342 CR457267 CAG33548 DA725217 DQ891801 ABM82727 DQ894985 ABM85911 XM_005268983 XP_005269040 XR_944589 NM_001307936 NP_001294865 NM_018976 NP_061849
Function Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. {ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15922329}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}; Multi-pass membrane protein {ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). {ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}.
Top Pathways Protein digestion and absorption, GABAergic synapse, Glutamatergic synapse

SLC38A2-Over-expression-Lysate - LY14926a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SLC38A2 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SLC38A2 gene‘

SLC38A2-knockout Cell lysate - LC810363 from Acris Antibodies

Category Cell Lysate
Prices $495.00
Sizes 100 µg

Panoply™ Human SLC38A2 Knockdown Stable Cell Line - CSC-DC014549 from Creative biogene

Category Cell Line
Species Human

Human SLC38A2 Knockout Cell Line-HeLa - CSC-RT0863 from Creative biogene

Category Cell Line
Species Human

SLC38A2 KO Cell Lysate-HeLa - CLKO-0364 from Creative biogene

Category Cell Lysate
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