| Gene Symbol |
LRRC8E
|
| Entrez Gene |
80131
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 8 family, member E
|
| Other Description |
leucine-rich repeat-containing protein 8E|volume-regulated anion channel subunit LRRC8E
|
| Swissprots |
Q7L236 B3KR78 Q2YDY3 Q6NSJ5 Q9H5H8 Q8N3B0
|
| Accessions |
EAW68969 Q6NSJ5 AK027073 BAB15648 AK091134 BAG52290 AL834474 CAD39133 AM393515 CAL38392 BC022216 AAH22216 BC070089 AAH70089 BC108252 AAI08253 BX538180 CB049178 CD109368 CF593782 DA447942 XM_011528319 XP_011526621 NM_001268284 NP_001255213 NM_001268285 NP_001255214 NM_025061 NP_079337
|
| Function |
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8E constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|