| Gene Symbol | RNPS1 |
|---|---|
| Entrez Gene | 10921 |
| Alt Symbol | E5.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RNA binding protein S1, serine-rich domain |
| Other Description | RNA-binding protein S1, serine-rich domain|RNA-binding protein with serine-rich domain 1|SR protein|SR-related protein LDC2 |
| Swissprots | B4DZU7 A8K1P0 Q15287 Q32P25 O75308 B7ZA17 B4DDU8 Q9NYG3 Q8WY42 |
| Accessions | EAW85516 EAW85517 EAW85518 EAW85519 EAW85520 EAW85521 EAW85522 Q15287 AB445101 BAI99736 AF015608 AAC39791 AF247662 AAF72519 AF274003 AAL56665 AK021799 AK091886 AK092131 AK289955 BAF82644 AK293343 BAG56859 AK303100 BAG64209 AK316132 BAH14503 AL520572 AL559988 BC001659 AAH01659 BC001838 AAH01838 BC108316 AAI08317 BG716139 BI819738 BQ059026 DA062271 DA728900 DA732377 DA818573 DQ574166 DQ895514 ABM86440 EU176344 ABW03795 HY012482 L37368 AAA92859 XM_005255048 XP_005255105 XM_005255049 XP_005255106 NM_001286625 NP_001273554 NM_001286626 NP_001273555 NM_001286627 NP_001273556 NM_006711 NP_006702 NM_080594 NP_542161 NR_104485 |
| Function | Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in d |
| Subcellular Location | Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:8543184}. |
| Top Pathways | RNA transport, mRNA surveillance pathway |