| Gene Symbol |
LAMB1
|
| Entrez Gene |
3912
|
| Alt Symbol |
CLM, LIS5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
laminin, beta 1
|
| Other Description |
laminin B1 chain|laminin subunit beta-1
|
| Swissprots |
Q14D91 P07942
|
| Accessions |
AAA59485 AAA59486 AAS07514 CCQ43174 EAL24388 EAW83423 EAW83424 P07942 AK303501 BAG64534 AK307611 AK309921 BC026018 AAH26018 BC044633 BC052598 BC113455 AAI13456 BX648251 DA861108 M20206 AAA59487 M61916 AAA59482 XM_011516203 XP_011514505 NM_002291 NP_002282
|
| Function |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Toxoplasmosis
|