| Gene Symbol |
TRAF2
|
| Entrez Gene |
7186
|
| Alt Symbol |
MGC:45012, TRAP, TRAP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TNF receptor-associated factor 2
|
| Other Description |
E3 ubiquitin-protein ligase TRAF2|tumor necrosis factor type 2 receptor associated protein 3|tumor necrosis factor type 2 receptor-associated protein 3
|
| Swissprots |
Q7Z337 B4DPJ7 A8K107 Q12933 Q96NT2
|
| Accessions |
AAT27320 EAW88299 EAW88300 EAW88301 EAW88302 EAW88303 EAW88304 EAW88305 Q12933 AK054686 BAB70792 AK222961 AK289722 BAF82411 AK294607 BAG57794 AK298370 BAG60609 BC032410 AAH32410 BC033810 AAH33810 BC043492 AAH43492 BC064662 AAH64662 BM785733 BX538160 CAD98040 DQ893616 ABM84542 DQ894764 ABM85690 EU831941 ACE87382 EU831961 ACE87402 EU832036 ACE86698 EU832054 ACE86716 HM991672 ADQ89802 XM_005266099 XP_005266156 XM_011518973 XP_011517275 XM_011518974 XP_011517276 XM_011518975 XP_011517277 XM_011518976 XP_011517278 XM_011518977 XP_011517279 XM_011518978 XP_011517280 NM_021138 NP_066961
|
| Function |
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. {ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:18981220, E
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:19150425}.
|
| Top Pathways |
Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, TNF signaling pathway, Epstein-Barr virus infection, Sphingolipid signaling pathway
|