TRAF2

Gene Symbol TRAF2
Entrez Gene 7186
Alt Symbol MGC:45012, TRAP, TRAP3
Species Human
Gene Type protein-coding
Description TNF receptor-associated factor 2
Other Description E3 ubiquitin-protein ligase TRAF2|tumor necrosis factor type 2 receptor associated protein 3|tumor necrosis factor type 2 receptor-associated protein 3
Swissprots Q7Z337 B4DPJ7 A8K107 Q12933 Q96NT2
Accessions AAT27320 EAW88299 EAW88300 EAW88301 EAW88302 EAW88303 EAW88304 EAW88305 Q12933 AK054686 BAB70792 AK222961 AK289722 BAF82411 AK294607 BAG57794 AK298370 BAG60609 BC032410 AAH32410 BC033810 AAH33810 BC043492 AAH43492 BC064662 AAH64662 BM785733 BX538160 CAD98040 DQ893616 ABM84542 DQ894764 ABM85690 EU831941 ACE87382 EU831961 ACE87402 EU832036 ACE86698 EU832054 ACE86716 HM991672 ADQ89802 XM_005266099 XP_005266156 XM_011518973 XP_011517275 XM_011518974 XP_011517276 XM_011518975 XP_011517277 XM_011518976 XP_011517278 XM_011518977 XP_011517279 XM_011518978 XP_011517280 NM_021138 NP_066961
Function Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. {ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:18981220, E
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:19150425}.
Top Pathways Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, TNF signaling pathway, Epstein-Barr virus infection, Sphingolipid signaling pathway

Phospho-TRAF2 (Ser11) (E2B6L) Rabbit mAb - 13908 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E2B6L
Western blot analysis of extracts from THP-1 cells differentiated with TPA #4174 (80 nM, overnight), and then either untreated (-) or transfected with poly(dA:dT) (0.004 U/ml; 7 hr; +), using Phospho-TRAF2 (Ser11) (E2B6L) Rabbit mAb (upper) or TRAF2 (C192) Antibody #4724 (lower).

TRAF2 Antibody - 4712 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from THP1 and Ramos cells, using TRAF2 Antibody.

TRAF2 (C192) Antibody - 4724 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat, 293, HeLa, C2C12, and NIH/3T3 cells, using TRAF2 (C192) Antibody.

TRAF2 (D-12) - sc-365287 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAF2 (D-12): sc-365287. Western blot analysis of TRAF2 expression in non-transfected: sc-117752 (A) and human TRAF2 transfected: sc-172765 (B) 293T whole cell lysates.

TRAF2 (C-20) - sc-876 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of TRAF2 expression in Jurkat (A,D), A-431 (B,E) and WEHI-231 (C,F) whole cell lysates. Antibodies tested include TRAF2 (C-20): sc-876 (A-C) and TRAF2 (N-19): sc-877 (D-F).

TRAF2 (D-3) - sc-136997 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAF2 (D-3): sc-136997. Western blot analysis of TRAF2 expression in non-transfected 293T: sc-117752 (A), human TRAF2 transfected 293T: sc-172526 (B) and Jurkat (C) whole cell lysates.

TRAF2 (F-2) - sc-136999 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAF2 (F-2): sc-136999. Western blot analysis of TRAF2 expression in non-transfected 293T: sc-117752 (A), human TRAF2 transfected 293T: sc-178079 (B) and Jurkat (C) whole cell lysates.

TRAF2 (F-4) - sc-137048 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAF2 (F-4): sc-137048. Western blot analysis of TRAF2 expression in non-transfected 293T: sc-117752 (A), human TRAF2 transfected 293T: sc-172526 (B) and Jurkat (C) whole cell lysates.

TRAF2 (G-3) - sc-136998 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAF2 (G-3): sc-136998. Western blot analysis of TRAF2 expression in HeLa (A) and A-431 (B) whole cell lysates.

TRAF2 (H-10) - sc-7346 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAF2 (H-10): sc-7346. Western blot analysis of TRAF2 expression in COS cells transfected with TRAF2.

TRAF2 (N-19) - sc-877 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRAF2 (N-19): sc-877. Western blot analysis of lysates prepared from control COS cells (A), COS cells transfected with a TRAF2 expression vector (B) and Jurkat cells (C).

TRAF2 (H-249) - sc-7187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRAF2 (H-249): sc-7187. Western blot analysis of TRAF2 expression in Jurkat whole cell lysate.

Anti-TRAF2 antibody - ab37118 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TRAF2 antibody (ab37118) at 0.5 µg/mlLane 2 : Anti-TRAF2 antibody (ab37118) at 1 µg/mlLane 3 : Anti-TRAF2 antibody (ab37118) at 2 µg/mlLane 1 : Mouse liver tissue lysateLane 2 : Mouse liver tissue lysateLane 3 : Mouse liver tissue lysateLysates/proteins at 15 µg per lane.Secondarygoat anti-rabbit HRP at 1/10000 dilution

Anti-TRAF2 antibody - ab37119 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of TRAF2 in Human liver tissue with ab37119 at 20 ug/mL.

Anti-TRAF2 antibody - ab110198 from Abcam

Prices $384.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry analysis of formalin fixed, paraffin embedded human kidney tissue using ab110198 at 3.75 µg/ml.

Anti-TRAF2 antibody - ab60169 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-TRAF2 antibody (ab60169) at 0.1 µg/ml + Human Ovary lysate (35µg protein in RIPA buffer)

Anti-TRAF2 antibody - ab155273 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TRAF2 antibody (ab155273) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-TRAF2 antibody - ab172235 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TRAF2 antibody (ab172235) at 1 µg/mlLane 1 : TRAF2-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H+L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-TRAF2 antibody [33A1293] - ab12122 from Abcam

Prices $390.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 33A1293

Anti-TRAF2 antibody [EPR6048] - ab126758 from Abcam

Prices $99.00, $388.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6048
Overlay histogram showing HeLa cells fixed in 2% PFA and stained with purified ab126758 at a dilution of 1 in 120 (red line). The secondary antibody used was FITC goat anti-rabbit at a dilution of 1 in 150. Rabbit monoclonal IgG was used as an isotype control (black) and cells without antibody were used as a negative control (blue).

Anti-TRAF2 antibody [EPR6048] (Alexa Fluor® 488) - ab198971 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6048
ab198971 staining TRAF2 in HeLa cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab198971 at 1/500 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 2µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-TRAF2 antibody [EPR7064] - ab167163 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7064
All lanes : Anti-TRAF2 antibody [EPR7064] (ab167163) at 1/1000 dilutionLane 1 : Molt-4 cell lysateLane 2 : 293T cell lysateLane 3 : Raji cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit at 1/2000 dilution

Anti-TRAF2 Antibody (N-Terminus, clone EPR6048) IHC-plus™ - LS-B8982 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6048
Anti-TRAP / TRAF2 antibody IHC staining of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TRAF2 Antibody (clone 4C11) - LS-C198366 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C11
Western Blot analysis of TRAF2 expression in transfected 293T cell line by TRAF2 monoclonal antibody (M04), clone 4C11.Lane 1: TRAF2 transfected lysate(55.9 KDa).Lane 2: Non-transfected lysate.

Anti-TRAF2 Antibody (C-Terminus, Azide-free, HRP) - LS-C226509 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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