TRAF2

Gene Symbol	TRAF2
Entrez Gene	7186
Alt Symbol	MGC:45012, TRAP, TRAP3
Species	Human
Gene Type	protein-coding
Description	TNF receptor-associated factor 2
Other Description	E3 ubiquitin-protein ligase TRAF2|tumor necrosis factor type 2 receptor associated protein 3|tumor necrosis factor type 2 receptor-associated protein 3
Swissprots	Q7Z337 B4DPJ7 A8K107 Q12933 Q96NT2
Accessions	AAT27320 EAW88299 EAW88300 EAW88301 EAW88302 EAW88303 EAW88304 EAW88305 Q12933 AK054686 BAB70792 AK222961 AK289722 BAF82411 AK294607 BAG57794 AK298370 BAG60609 BC032410 AAH32410 BC033810 AAH33810 BC043492 AAH43492 BC064662 AAH64662 BM785733 BX538160 CAD98040 DQ893616 ABM84542 DQ894764 ABM85690 EU831941 ACE87382 EU831961 ACE87402 EU832036 ACE86698 EU832054 ACE86716 HM991672 ADQ89802 XM_005266099 XP_005266156 XM_011518973 XP_011517275 XM_011518974 XP_011517276 XM_011518975 XP_011517277 XM_011518976 XP_011517278 XM_011518977 XP_011517279 XM_011518978 XP_011517280 NM_021138 NP_066961
Function	Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. {ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:18981220, E
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:19150425}.
Top Pathways	Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, TNF signaling pathway, Epstein-Barr virus infection, Sphingolipid signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRAF2 full length protein - ab152764 from Abcam Category Protein Source Wheat germ Species Human

Human TRAF2 peptide - ab40026 from Abcam Category Peptide Species Human

Human TRAF2 peptide - ab40027 from Abcam Category Peptide Species Human

Recombinant Human TRAF-2 Protein - H00007186-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRAF-2 Blocking Peptide - NBP1-77248PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TRAF-2 Peptide - NBP1-77247PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

TRAF-2 Peptide - P2849 from Novus Biologicals Category Peptide Species Human

TRAF-2 Peptide - P2848 from Novus Biologicals Category Peptide Species Human

TRAF2-Antibody-Center-Blocking-peptide - BP13857c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRAF2-Antibody-Center-Blocking-Peptide - BP7825c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRAF2-Antibody-C-term-Blocking-Peptide - BP7825b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRAF2 Protein Lysate (APL10344) - APL10344 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

TRAF2 Protein Lysate (APL10557) - APL10557 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

TRAF2 Protein Lysate (APL10558) - APL10558 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human TNF receptor-Associated Factor 2 protein - orb81428 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 10 μg, 50 μg Source E.coli Species Human

TRAF2 peptide - orb73294 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

TANK protein - 30R-1306 from Fitzgerald Category Protein Prices $230.00 Sizes 100 µg Source E.coli

TANK protein (His tag) - 80R-2648 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

TRAF2 Peptide - AC21-0888-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRAF2 / TRAP3 - H00007186-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRAF2 / TRAP3 - H00007186-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRAF2 / TRAP3 Control Peptide - AP30934CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TRAF2 / TRAP3 Control Peptide - AP30935CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TRAF2 Peptide - 46-510P from ProSci Category Peptide Species Human

TRAF2 Peptide - 3661P from ProSci Category Peptide Species Human

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