| Gene Symbol |
P3h1
|
| Entrez Gene |
56401
|
| Alt Symbol |
2410024C15Rik, Gros1, Lepre1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
prolyl 3-hydroxylase 1
|
| Other Description |
growth suppressor 1|leprecan 1|leprecan-1|leucine- and proline-enriched proteoglycan 1
|
| Swissprots |
Q8BSV2 A6PW85 Q8CFL3 Q3V1T4 Q9CWK5 Q9QZT6 Q9QZT7 Q3TWX8 A2A7Q4
|
| Accessions |
EDL30456 EDL30457 EDL30458 Q3V1T4 AF165163 AAF04806 AF165164 AAF04807 AK010578 BAB27041 AK030436 BAC26962 AK132262 BAE21065 AK159505 BAE35138 AK165077 AK183740 AK187865 AK193263 AK214845 AK217893 BB617770 BC024047 AAH24047 BY240019 CO040878 CX563255 NM_001042411 NP_001035874 NM_001286148 NP_001273077 NM_019782 NP_062756 NM_019783 NP_062757
|
| Function |
Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum {ECO:0000255|PROSITE- ProRule:PRU10138}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG).
|
