Gene Symbol | P3h1 |
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Entrez Gene | 56401 |
Alt Symbol | 2410024C15Rik, Gros1, Lepre1 |
Species | Mouse |
Gene Type | protein-coding |
Description | prolyl 3-hydroxylase 1 |
Other Description | growth suppressor 1|leprecan 1|leprecan-1|leucine- and proline-enriched proteoglycan 1 |
Swissprots | Q8BSV2 A6PW85 Q8CFL3 Q3V1T4 Q9CWK5 Q9QZT6 Q9QZT7 Q3TWX8 A2A7Q4 |
Accessions | EDL30456 EDL30457 EDL30458 Q3V1T4 AF165163 AAF04806 AF165164 AAF04807 AK010578 BAB27041 AK030436 BAC26962 AK132262 BAE21065 AK159505 BAE35138 AK165077 AK183740 AK187865 AK193263 AK214845 AK217893 BB617770 BC024047 AAH24047 BY240019 CO040878 CX563255 NM_001042411 NP_001035874 NM_001286148 NP_001273077 NM_019782 NP_062756 NM_019783 NP_062757 |
Function | Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum {ECO:0000255|PROSITE- ProRule:PRU10138}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG). |
Gros1 CRISPR/Cas9 KO Plasmid (m) - sc-425139 from Santa Cruz Biotechnology
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Gros1 HDR Plasmid (m) - sc-425139-HDR from Santa Cruz Biotechnology
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Gros1 Double Nickase Plasmid (m) - sc-425139-NIC from Santa Cruz Biotechnology
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Gros1 Double Nickase Plasmid (m2) - sc-425139-NIC-2 from Santa Cruz Biotechnology
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Gros1 CRISPR Activation Plasmid (m) - sc-425139-ACT from Santa Cruz Biotechnology
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Gros1 CRISPR Activation Plasmid (m2) - sc-425139-ACT-2 from Santa Cruz Biotechnology
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Gros1 Lentiviral Activation Particles (m) - sc-425139-LAC from Santa Cruz Biotechnology
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Gros1 Lentiviral Activation Particles (m2) - sc-425139-LAC-2 from Santa Cruz Biotechnology
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Gros1 siRNA (m) - sc-37434 from Santa Cruz Biotechnology
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Gros1 shRNA Plasmid (m) - sc-37434-SH from Santa Cruz Biotechnology
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Gros1 shRNA (m) Lentiviral Particles - sc-37434-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN34721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34721 from Sigma-Aldrich
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LEPRE1 siRNA (Mouse) - CRM5775 from Cohesion Biosciences
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shRNA set against Mouse LEPRE1 (NM_019782.2) - SHH329635 from Creative biogene
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shRNA set against Mouse Lepre1(NM_019782.2) - SHH146495 from Creative biogene
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shRNA set against Mouse Lepre1(NM_019783.2) - SHH146531 from Creative biogene
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shRNA set against Mouse Lepre1(NM_001042411.1) - SHH146549 from Creative biogene
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Mouse LEPRE1 siRNA - orb285251 from Biorbyt
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LEPRE1 shRNA Plasmid (Mouse) - CHM5775 from Cohesion Biosciences
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LEPRE1 miRNA 3'UTR clone - MiUTR1M-06600 from Creative biogene
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LEPRE1 miRNA 3'UTR clone - MiUTR1M-06601 from Creative biogene
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