UBE2L3

Gene Symbol UBE2L3
Entrez Gene 7332
Alt Symbol E2-F1, L-UBC, UBCH7, UbcM4
Species Human
Gene Type protein-coding
Description ubiquitin-conjugating enzyme E2L 3
Other Description ubiquitin carrier protein L3|ubiquitin-conjugating enzyme E2 L3|ubiquitin-conjugating enzyme E2-F1|ubiquitin-conjugating enzyme UBCH7|ubiquitin-protein ligase L3
Swissprots Q9HAV1 B4DSZ4 P68036 B4DDG1 P70653 P51966 E7EWS7 B2R4A7
Accessions CBJ21215 EAW59459 EAW59460 P68036 AJ000519 CAA04156 AK125396 AK291083 BAF83772 AK293179 BAG56722 AK299985 BAG61806 AK311761 BAG34704 BC053368 AAH53368 BU567707 BU584304 CD690076 CR456606 CAG30492 CU013202 CAK54633 CU013490 CAK54932 DA271653 S81003 AAB36017 X92962 CAA63538 NM_001256355 NP_001243284 NM_001256356 NP_001243285 NM_003347 NP_003338 NR_028436 NR_046082 NM_198157
Function Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:15367689, ECO:0000269|PubMed:17003263, ECO:0000269|PubMed:18946090, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:2153
Subcellular Location Nucleus. Cytoplasm.
Tissue Specificity Ubiquitous, with highest expression in testis.
Top Pathways Ubiquitin mediated proteolysis

UBE2L3 (D5G1) Rabbit mAb - 8721 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5G1
Western blot analysis of extracts from various cell lines using UBE2L3 (D5G1) Rabbit mAb.

UBE2L3 Antibody - 3848 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using UBE2L3 Antibody.

UBE2L3 (A-5) - sc-376517 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE2L3 (A-5): sc-376517. Western blot analysis of UBE2L3 expression in non-transfected 293T: sc-117752 (A), mouse UBE2L3 transfected 293T: sc-124407 (B) and HeLa (C) whole cell lysates.

UBE2L3 (B-11) - sc-390032 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE2L3 (B-11): sc-390032. Western blot analysis of UBE2L3 expression in HeLa whole cell lysate.

UBE2L3 (E-2) - sc-390234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE2L3 (E-2): sc-390234. Western blot analysis of UBE2L3 expression in non-transfected 293T: sc-117752 (A), human UBE2L3 transfected 293T: sc-116434 (B) and HeLa (C) whole cell lysates.

UBE2L3 (C-20) - sc-47549 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UBE2L3 (C-20): sc-47549. Western blot analysis of UBE2L3 expression in non-transfected: sc-117752 (A) and human UBE2L3 transfected: sc-116434 (B) 293T whole cell lysates.

UBE2L3 (H-62) - sc-292775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

UBE2L3 (K-20) - sc-47550 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UBE2L3 (K-20): sc-47550. Western blot analysis of UBE2L3 expression in K-562 (A), Jurkat (B) and NTERA-2 cl.D1 (C) whole cell lysates.

Anti-Ube2L3 antibody - ab97277 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ube2L3 antibody (ab97277) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Ube2L3 antibody - ab58262 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Ube2L3 antibody (ab58262) used in immunofluorescence at 10ug/ml on HeLa cells.

Anti-Ube2L3 antibody [EPR4368] - ab108936 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4368
All lanes : Anti-Ube2L3 antibody [EPR4368] (ab108936) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : LNCaP cell lysateLane 3 : Jurkat cell lysateLane 4 : K562 cell lysateLysates/proteins at 10 µg per lane.

Anti-Ube2L3 antibody - N-terminal - ab71802 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Ube2L3 antibody - N-terminal (ab71802) at 1/100 dilution + HL-60 cell lysate at 12.5 µg

Anti-UBE2L3 / UBCH7 Antibody (Internal, clone EPR4368) IHC-plus™ - LS-B10164 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4368
Anti-UBE2L3 / UBCH7 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-UBE2L3 / UBCH7 Antibody (C-Terminus) IHC-plus™ - LS-B3552 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-UBE2L3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3552 concentration 5 ug/ml.

Anti-UBE2L3 / UBCH7 Antibody (C-Terminus) - LS-C93193 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UBE2L3 / UBCH7 Antibody (aa110-122) - LS-C20223 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Staining (0.5 ug/ml) of HeLa lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by chemiluminescence.

Anti-UBE2L3 / UBCH7 Antibody (C-Terminus) - LS-C31944 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
UBE2L3 antibody LS-C31944 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-UBE2L3 / UBCH7 Antibody (aa106-135, AP) - LS-C272903 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2L3 / UBCH7 Antibody (aa106-135, APC) - LS-C272904 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2L3 / UBCH7 Antibody (aa106-135, Biotin) - LS-C272905 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2L3 / UBCH7 Antibody (aa106-135, FITC) - LS-C272906 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2L3 / UBCH7 Antibody (aa106-135, Azide-free, HRP) - LS-C272907 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2L3 / UBCH7 Antibody (aa106-135, PE) - LS-C272909 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2L3 / UBCH7 Antibody (N-Terminus, APC) - LS-C283996 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2L3 / UBCH7 Antibody (N-Terminus, AP) - LS-C283997 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more